Targeting of tumor cells by custom antigen transfer: a novel approach for immunotherapy of cancer

Frontiers in Oncology

Oncology

Alice Santi¹  Paolo Cirri¹  Anna Caselli¹  Ilaria Nesi¹  Erica Pranzini¹  Paolo Paoli¹  Matteo Ramazzotti¹  Massimo Genovese¹  Maria Letizia Taddei²  Chiara Della Bella³  Mario Milco D’Elios⁴ 

[1] Department of Experimental and Clinical Biomedical Sciences, University of Firenze, Firenze, Italy;Department of Experimental and Clinical Medicine, University of Firenze, Firenze, Italy;Department of Experimental and Clinical Medicine, University of Firenze, Firenze, Italy;Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy;Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy;

关键词: immunotherapy;    immunotargeting;    cancer therapy;    tumor microenvironment;    extracellular vesicles;    microvesicles;    ectosomes;   

DOI  :  10.3389/fonc.2023.1245248

 received in 2023-06-23, accepted in 2023-09-19,  发布年份 2023

来源: Frontiers

【 摘 要 】

In the early stages of carcinogenesis, the transformed cells become “invisible” to the immune system. From this moment on, the evolution of the tumor depends essentially on the genotype of the primitive cancer cells and their subsequent genetic drift. The role of the immune system in blocking tumor progression from the earliest stages is largely underestimated because by the time tumors are clinically detectable, the immune system has already completely failed its task. Therefore, a clinical treatment capable of restoring the natural anti-tumor role of the immune system could prove to be the “ultimate weapon” against cancer. Herein, we propose a novel therapeutic approach for the treatment of solid cancer that exploits the capability of activated monocytes to transfer major histocompatibility complex I (MHC-I) molecules bound to antigenic peptides to cancer cells using microvesicles as cargo, making tumor cells target of a “natural” CD8+ T lymphocyte cytotoxic response.

【 授权许可】

Unknown   
Copyright © 2023 Nesi, Della Bella, Taddei, Santi, Pranzini, Paoli, D’Elios, Ramazzotti, Genovese, Caselli and Cirri