Cardiovascular sex-differences: insights via physiology-based modeling and potential for noninvasive sensing via ballistocardiography

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Craig A. Emter¹  Virginia H. Huxley²  Marjorie Skubic³  Giovanna Guidoboni⁴  Mohamed Zaid⁵  Mihail Popescu⁶  David Heise⁷  Laurel Despins⁸  Salman Ahmad⁹  Lorenzo Sala^1,10 

[1] Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, MO, United States;Department of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, MO, United States;National Center for Gender Physiology, University of Missouri, Columbia, MO, United States;Electrical Engineering and Computer Science, College of Engineering, University of Missouri, Columbia, MO, United States;Electrical and Computer Engineering, Maine College of Engineering and Computing, University of Maine, Orono, ME, United States;Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME, United States;Health Management and Informatics, School of Medicine, University of Missouri, Columbia, MO, United States;Science, Technology & Mathematics, College of Arts and Sciences, Lincoln University, Jefferson City, MO, United States;Sinclair School of Nursing, University of Missouri, Columbia, MO, United States;Surgery, School of Medicine, University of Missouri, Columbia, MO, United States;Université Paris-Saclay, INRAE, MaIAGE, Jouy-en-Josas, France;

关键词: cardiovascular sex differences;    noninvasive sensing;    ballistocardiography;    cardiovascular modeling;    sex differeces;    physiology-based modeling;   

DOI  :  10.3389/fcvm.2023.1215958

 received in 2023-05-03, accepted in 2023-09-12,  发布年份 2023

来源: Frontiers

【 摘 要 】

In this study, anatomical and functional differences between men and women in their cardiovascular systems and how these differences manifest in blood circulation are theoretically and experimentally investigated. A validated mathematical model of the cardiovascular system is used as a virtual laboratory to simulate and compare multiple scenarios where parameters associated with sex differences are varied. Cardiovascular model parameters related with women’s faster heart rate, stronger ventricular contractility, and smaller blood vessels are used as inputs to quantify the impact (i) on the distribution of blood volume through the cardiovascular system, (ii) on the cardiovascular indexes describing the coupling between ventricles and arteries, and (iii) on the ballistocardiogram (BCG) signal. The model-predicted outputs are found to be consistent with published clinical data. Model simulations suggest that the balance between the contractile function of the left ventricle and the load opposed by the arterial circulation attains similar levels in females and males, but is achieved through different combinations of factors. Additionally, we examine the potential of using the BCG waveform, which is directly related to cardiovascular volumes, as a noninvasive method for monitoring cardiovascular function. Our findings provide valuable insights into the underlying mechanisms of cardiovascular sex differences and may help facilitate the development of effective noninvasive cardiovascular monitoring methods for early diagnosis and prevention of cardiovascular disease in both women and men.

【 授权许可】

Unknown   
© 2023 Zaid, Sala, Despins, Heise, Popescu, Skubic, Ahmad, Emter, Huxley and Guidoboni.