Transcutaneous cervical vagus nerve stimulation improved motor cortex excitability in healthy adults: a randomized, single-blind, self-crossover design study

Frontiers in Neuroscience

Neuroscience

Yoshitaka Oku¹  Yao-Wen Zhang²  Zhi-Yong Peng³  Meng-Fei Zhang³  Zi Huang³  Aihaiti Wumiti⁴  Meng-Xin Wang⁴  Zhi-Ming Tang⁴  Xue-Sheng Gao⁵ 

[1] Department of Physiology, Hyogo Medical University, Hyogo, Japan;Department of Rehabilitation Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;Department of Rehabilitation Medicine, Yuedong Hospital, The Third Affiliated Hospital of Sun Yat-sen University, Meizhou, China;Department of Rehabilitation Medicine, Yuedong Hospital, The Third Affiliated Hospital of Sun Yat-sen University, Meizhou, China;Department of Rehabilitation Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;Rehabilitation Medicine Department, Affiliated Hospital of Weifang Medical University, Weifang, China;

关键词: noninvasive vagus nerve stimulation;    motor cortex excitability;    neuromodulation;    transcranial magnetic stimulation;    motor evoke potential;   

DOI  :  10.3389/fnins.2023.1234033

 received in 2023-06-20, accepted in 2023-09-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

PurposeTo investigate the effect of transcutaneous cervical vagus nerve stimulation (tcVNS) on motor cortex excitability in healthy adults.MethodTwenty eight healthy subjects were assigned to receive real and sham tcVNS for 30 min. The interval between the real and sham conditions was more than 24 h, and the sequence was random. The central and peripheral motor-evoked potential (MEP) of the right first dorsal interosseous (FDI) muscle was measured by transcranial magnetic stimulation (TMS) before and after stimulation. MEP latency, MEP amplitude and rest motor threshold (rMT) were analyzed before and after stimulation.ResultsMEP amplitude, MEP latency and rMT had significant interaction effect between time points and conditions (p < 0.05). After real stimulation, the MEP amplitude was significantly increased (p < 0.001). MEP latency (p < 0.001) and rMT (p = 0.006) was decreased than that of baseline. The MEP amplitude on real condition was higher than that of sham stimulation after stimulation (p = 0.027). The latency after the real stimulation was significantly shorter than that after sham stimulation (p = 0.005). No significantly difference was found in rMT after stimulation between real and sham conditions (p > 0.05).ConclusiontcVNS could improve motor cortex excitability in healthy adults.

【 授权许可】

Unknown   
Copyright © 2023 Wang, Wumiti, Zhang, Gao, Huang, Zhang, Peng, Oku and Tang.