Influence of age and fitness level on immune responses of T and NK cells in healthy physically active subjects after strenuous aerobic exercise: a cross-sectional study

Frontiers in Immunology

Immunology

Jason R. Jaggers¹  Radamés Maciel Vitor Medeiros²  Valéria Soraya de Farias Sales³  Phelipe Wilde³  Ciro Alexandre Mercês Gonçalves³  Breno Guilherme de Araújo Tinôco Cabral⁴  Paulo Francisco de Almeida-Neto⁴  Paulo Moreira Silva Dantas⁴  Geraldo Barroso Cavalcanti Júnior⁵ 

[1] Department of Health and Sport Sciences, University of Louisville, Louisville, KY, United States;Department of Physical Education, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil;Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil;Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil;Department of Physical Education, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil;Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil;Hemocentro Dalton Cunha - Hemonorte, Natal, Rio Grande do Norte, Brazil;

关键词: physical activity;    immune system;    leukocytes;    lymphocytes;    neutrophils;   

DOI  :  10.3389/fimmu.2023.1252506

 received in 2023-07-03, accepted in 2023-09-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

AimThe aim of this study is to analyze whether immune responses after strenuous exercise are influenced by chronological age and fitness level in physically active healthy men.MethodsCross-sectional study with a sample of 32 physically active men. Participants were divided into two groups based on chronological age (younger: age 21.8 ± 1.8 vs. older: age 34.6 ± 8.3) and subsequently regrouped and divided based on fitness level (More conditioned: excellent and superior VO2max vs. Less conditioned: VO2max: weak, regular and good). Fitness was classified according to VO2max levels obtained by a treadmill test using a gas analyzer. Before and immediately after the ergospirometry test, blood samples were collected for evaluation of immunological markers: leukocytes, neutrophils, lymphocytes and subpopulations.ResultsChronological age had a moderate effect on CD3+CD4+ lymphocyte count (effect size: 0.204) and CD4/CD8 ratio (effect size: 0.278), favoring older subjects. The level of physical fitness had no significant effect on the analyzed immunological markers.ConclusionsImmune responses observed immediately after strenuous exercise may be more dependent on chronological age than on fitness level in healthy, physically active men.

【 授权许可】

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Copyright © 2023 Almeida-Neto, Gonçalves, Wilde, Jaggers, Júnior, de Farias Sales, Medeiros, Dantas and Cabral