The Immunology of Takotsubo Syndrome

Frontiers in Immunology

Immunology

Kenji Rowel Q. Lim¹  Douglas L. Mann¹  Tomohiro Hayashi²  Tsuneaki Kenzaka² 

[1] Division of Cardiology, Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO, United States;Division of Community Medicine and Career Development, Kobe University Graduate School of Medicine, Kobe, Japan;Department of Internal Medicine, Hyogo Prefectural Tamba Medical Center, Tamba, Japan;

关键词: Takotsubo syndrome;    stress-induced cardiomyopathy;    acute cardiac injury;    inflammation;    catecholamine stress;    animal models;   

DOI  :  10.3389/fimmu.2023.1254011

 received in 2023-07-06, accepted in 2023-09-19,  发布年份 2023

来源: Frontiers

【 摘 要 】

Takotsubo syndrome (TTS) is a disorder characterized by transient cardiac dysfunction with ventricular regional wall motion abnormalities, primarily thought to be caused by the effects of a sudden catecholamine surge on the heart. Although the majority of patients exhibit prompt recovery of their cardiac dysfunction, TTS remains associated with increased mortality rates acutely and at long-term, and there is currently no cure for TTS. Inflammation has been shown to play a key role in determining outcomes in TTS patients, as well as in the early pathogenesis of the disorder. There are also cases of TTS patients that have been successfully treated with anti-inflammatory therapies, supporting the importance of the inflammatory response in TTS. In this article, we provide a comprehensive review of the available clinical and pre-clinical literature on the immune response in TTS, in an effort to not only better understand the pathophysiology of TTS but also to generate insights on the treatment of patients with this disorder.

【 授权许可】

Unknown   
Copyright © 2023 Lim, Mann, Kenzaka and Hayashi