Relationship between plasma leucine-rich α-2-glycoprotein 1 and urinary albumin excretion in patients with type 2 diabetes

Frontiers in Endocrinology

Endocrinology

Jin Ook Chung¹  Dong Hyeok Cho¹  Min Young Chung¹  Dong Jin Chung¹  Seon-Young Park² 

[1] Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea;Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea;

关键词: albuminuria;    biomarkers;    diabetes mellitus;    type 2;    diabetic nephropathies;    LRG1 protein;   

DOI  :  10.3389/fendo.2023.1232021

 received in 2023-05-31, accepted in 2023-09-19,  发布年份 2023

来源: Frontiers

【 摘 要 】

AimsTo explore the relationship between plasma leucine-rich α-2-glycoprotein 1 (LRG1) level and the degree of urinary albumin excretion in patients with type 2 diabetes.MethodsWe evaluated 332 patients with type 2 diabetes in a cross-sectional study.ResultThe plasma LRG1 level differed significantly according to the quartiles of urinary albumin excretion (Q1 [<7.7 mg/g], 17.1 μg/mL; Q2 [7.7–15.0 mg/g], 17.5 μg/mL; Q3 [15.1–61.4 mg/g], 18.6 μg/mL; Q4 [≥61.5 mg/g], 22.3 μg/mL; p for trend = 0.003) under adjustment with other covariates. A positive correlation was found between plasma LRG1 level and urinary albumin excretion (ρ = 0.256, p <0.001). According to a multivariate model, the association between LRG1 and urinary albumin excretion remained significant, under adjustment for confounding factors (β = 0.285, p <0.001).ConclusionPlasma LRG1 level was independently associated with urinary albumin excretion in patients with type 2 diabetes. This study suggests that LRG1 may be associated with increased excretion of urinary albumin in the early stages of diabetic nephropathy.

【 授权许可】

Unknown   
Copyright © 2023 Chung, Park, Cho, Chung and Chung