The double-edged sword role of hydrogen sulfide in hepatocellular carcinoma

Frontiers in Pharmacology

Pharmacology

Saadullah Khattak¹  Huijie Zhao²  Xiaodi Fu³  Honggang Wang³  Yanting Zhang⁴  Chaoren Chen⁵ 

[1] Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan, China;School of Life Sciences, Henan University, Kaifeng, China;Institute of Chronic Disease Risks Assessment, Henan University, Kaifeng, China;School of Basic Medical Sciences, Henan University, Kaifeng, Henan, China;School of Basic Medical Sciences, Henan University, Kaifeng, Henan, China;School of Clinical Medicine, Henan University, Kaifeng, Henan, China;School of Nursing and Health, Institute of Nursing and Health, Henan University, Kaifeng, Henan, China;

关键词: hydrogen sulfide;    hepatocellular carcinoma;    apoptosis;    cystathione gamma-lyase;    3-mercaptopyruvate sulfurtransferase;   

DOI  :  10.3389/fphar.2023.1280308

 received in 2023-08-21, accepted in 2023-10-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

With an increasing worldwide prevalence, hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver in the world. It is also the primary reason for cancer-related death in the world. The pathogenesis of HCC is complex, such as DNA methylation changes, immune regulatory disorders, cell cycle disorders, chromosomal instability, and so on. Although many studies have been conducted on HCC, the molecular mechanisms of HCC are not completely understood. At present, there is no effective treatment for HCC. Hydrogen sulfide (H2S) has long been regarded as a toxic gas with the smell of rotten eggs, but recent studies have shown that it is an important gasotransmitter along with carbon monoxide (CO) and nitric oxide (NO). Increasing evidence indicates that H2S has multiple biological functions, such as anti-inflammation, anti-apoptosis, anti-oxidative stress, and so on. Recently, a lot of evidence has shown that H2S has a “double-edged sword” effect in HCC, but the mechanism is not fully understood. Here, we reviewed the progress on the role and mechanism of H2S in HCC in recent years, hoping to provide a theoretical reference for future related research.

【 授权许可】

Unknown   
Copyright © 2023 Zhao, Zhang, Fu, Chen, Khattak and Wang.