Different doses of intermittent theta burst stimulation for upper limb motor dysfunction after stroke: a study protocol for a randomized controlled trial

Frontiers in Neuroscience

Neuroscience

Kaiyue Han¹  Qianqian Chi¹  Zhiqing Tang¹  Ying Liu¹  Xiaonian Zhang¹  Jingdu Zhao¹  Tianhao Liu¹  Wenlong Su²  Hao Zhang³ 

[1] School of Rehabilitation, Capital Medical University, Beijing, China;China Rehabilitation Research Center, Beijing Bo'ai Hospital, Beijing, China;School of Rehabilitation, Capital Medical University, Beijing, China;China Rehabilitation Research Center, Beijing Bo'ai Hospital, Beijing, China;University of Health and Rehabilitation Sciences, Qingdao, China;School of Rehabilitation, Capital Medical University, Beijing, China;China Rehabilitation Research Center, Beijing Bo'ai Hospital, Beijing, China;University of Health and Rehabilitation Sciences, Qingdao, China;Cheeloo College of Medicine, Shandong University, Jinan, China;

关键词: study protocol;    stroke;    intermittent theta burst stimulation;    upper limb;    randomized controlled trial;   

DOI  :  10.3389/fnins.2023.1259872

 received in 2023-07-20, accepted in 2023-09-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundUpper limb motor recovery is one of the important goals of stroke rehabilitation. Intermittent theta burst stimulation (iTBS), a new type of repetitive transcranial magnetic stimulation (rTMS), is considered a potential therapy. However, there is still no consensus on the efficacy of iTBS for upper limb motor dysfunction after stroke. Stimulus dose may be an important factor affecting the efficacy of iTBS. Therefore, we aim to investigate and compare the effects and neural mechanisms of three doses of iTBS on upper limb motor recovery in stroke patients, and our hypothesis is that the higher the dose of iTBS, the greater the improvement in upper limb motor function.MethodsThis prospective, randomized, controlled trial will recruit 56 stroke patients with upper limb motor dysfunction. All participants will be randomized in a 1:1:1:1 ratio to receive 21 sessions of 600 pulses active iTBS, 1,200 pulses active iTBS, 1,800 pulses active iTBS, or 1,800 pulses sham iTBS in addition to conventional rehabilitation training. The primary outcome is the Fugl-Meyer Assessment of the Upper Extremity (FMA-UE) score from baseline to end of intervention, and the secondary outcomes are the Wolf Motor Function Test (WMFT), Grip Strength (GS), Modified Barthel Index (MBI), and Stroke Impact Scale (SIS). The FMA-UE, MBI, and SIS are assessed pre-treatment, post-treatment, and at the 3-weeks follow-up. The WMFT, GS, and resting-state functional magnetic resonance imaging (rs-fMRI) data will be obtained pre- and post-treatment.DiscussionThe iTBS intervention in this study protocol is expected to be a potential method to promote upper limb motor recovery after stroke, and the results may provide supportive evidence for the optimal dose of iTBS intervention.

【 授权许可】

Unknown   
Copyright © 2023 Tang, Liu, Liu, Han, Su, Zhao, Chi, Zhang and Zhang.