An investigation of age dependency in Dutch and Chinese values for EQ-5D-Y

Frontiers in Psychology

Psychology

Silvia Evers¹  Manuela Joore²  Brigitte Essers²  Carmen Dirksen²  Marcel F. Jonker³  Elly Stolk⁴  Pei Wang⁵ 

[1] Care and Public Health Research Institute (CAPHRI), Maastricht, Netherlands;Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre, Maastricht, Netherlands;Care and Public Health Research Institute (CAPHRI), Maastricht, Netherlands;Erasmus Choice Modelling Centre, Erasmus University Rotterdam, Rotterdam, Netherlands;EuroQol Research Foundation, Rotterdam, Netherlands;School of Public Health, Fudan University, Shanghai, China;

关键词: health state values;    age-dependency;    health related quality of life;    children;    EQ-5D-Y;   

DOI  :  10.3389/fpsyg.2023.1175402

 received in 2023-02-27, accepted in 2023-09-11,  发布年份 2023

来源: Frontiers

【 摘 要 】

AimsThe primary aim was to explore the age dependency of health state values derived via trade-offs between health-related quality of life (HRQoL) and life years in a discrete choice experiment (DCE). The secondary aim was to explore if people weigh life years and HRQoL differently for children, adolescents, adults, and older adults.MethodsParticipants from the general population of the Netherlands and China first completed a series of choice tasks offering choices between two EQ-5D-Y states with a given lifespan. The choice model captured the value of a year in full health, disutility determined by EQ-5D-Y, and a discount rate. Next, they received a slightly different choice task, offering choices between two lives that differed in HRQoL and life expectancy but produced the same number of quality-adjusted life years (QALYs). Participants were randomly assigned to fill out the survey for three or four age frames: a hypothetical person of 10, 15, 40, and 70 years (the last one only applicable to China) to allow the age dependency of the responses to be explored.ResultsA total of 1,234 Dutch and 1,818 Chinese people administered the survey. Controlling for time preferences, we found that the agreement of health state values for different age frames was generally stronger in the Netherlands than in China. We found no clear pattern of differences in the QALY composition in both samples. The probability distribution over response options varied most when levels for lifespan or severity were at the extremes of the spectrum.Conclusion/discussionThe magnitude and direction of age effects on values seemed dimension- and country specific. In the Netherlands, we found a few differences in dimension-specific weights elicited for 10- and 15-year-olds compared to 40-year-olds, but the overall age dependency of values was limited. A stronger age dependency of values was observed in China, where values for 70-year-olds differed strongly from the values for other ages. The appropriateness of using existing values beyond the age range for which they were measured needs to be evaluated in the local context.

【 授权许可】

Unknown   
Copyright © 2023 Essers, Wang, Stolk, Jonker, Evers, Joore and Dirksen.