Longitudinal evaluation of innate immune responses to three doses of CoronaVac vaccine

Frontiers in Immunology

Immunology

Min Liu¹  Tuo Ji²  Cheng Cao³  Tianzhi Chang⁴  Junfeng Jiang⁴  Fang Gong⁵  Yaping Dai⁶ 

[1] Department of Laboratory Medicine, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China;Department of Laboratory Medicine, Jiangnan University Medical Center, Wuxi, Jiangsu, China;Department of Laboratory Medicine, Jiangnan University Medical Center, Wuxi, Jiangsu, China;Department of Laboratory Medicine, Changzhou Jintan First People’s Hospital, Changzhou, Jiangsu, China;Department of Laboratory Medicine, Jiangnan University Medical Center, Wuxi, Jiangsu, China;Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China;Department of Laboratory Medicine, Jiangnan University Medical Center, Wuxi, Jiangsu, China;Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China;Department of Laboratory Medicine, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China;Department of Laboratory Medicine, The Fifth People’s Hospital of Wuxi Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China;

关键词: CoronaVac;    vaccination;    innate immunity;    monocytes;    natural killer cells;    IFN-γ;   

DOI  :  10.3389/fimmu.2023.1277831

 received in 2023-08-15, accepted in 2023-09-19,  发布年份 2023

来源: Frontiers

【 摘 要 】

The adaptive immune responses induced by inactivated COVID-19 vaccine has been extensively studied. However, few studies have analyzed the impact of COVID-19 vaccination on innate immune cells. Here in this study, we recruited 62 healthcare workers who received three doses of CoronaVac vaccine and longitudinally profiled the alterations of peripheral monocytes and NK cells during vaccination. The results showed that both the monocyte and NK cell subsets distribution were altered, although the frequencies of the total monocyte and NK cells remained stable during the vaccination. Additionally, we found that both the 2nd and 3rd dose of CoronaVac vaccination elicited robust IFN-γ-producing NK cell response. Our data provided necessary insights on innate immune responses in the context of three homologous CoronaVac dose vaccination, and supplied immunological basis for the future design of inactivated vaccines against SARS-CoV-2 or other viruses.

【 授权许可】

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Copyright © 2023 Cao, Jiang, Liu, Dai, Chang, Ji and Gong