Case report: Acute kidney injury as the initial manifestation of chronic lymphocytic leukemia/small lymphocytic lymphoma

Frontiers in Medicine

Medicine

Thorsten Wiech¹  Peter R. Mertens²  Sascha T. Bender²  Christian Gross²  Vanja Zeremski³ 

[1] Institute for Pathology, University Hospital Hamburg-Eppendorf, Hamburg, Germany;University Clinic for Nephrology and Hypertension, Diabetes and Endocrinology, Otto-von-Guericke University, Magdeburg, Germany;University Hospital for Hematology and Oncology, Otto-von-Guericke University, Magdeburg, Germany;

关键词: chronic lymphocytic leukemia/small lymphocytic lymphoma;    kidney involvement;    infiltration;    extranodal;    zanubrutinib acute kidney injury as initial manifestation of chronic lymphocytic leukemia/small lymphocytic lymphoma;    paraprotein;   

DOI  :  10.3389/fmed.2023.1279005

 received in 2023-08-17, accepted in 2023-09-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disorder often diagnosed after incidental finding of leukocytosis. Renal involvement is usually clinically silent. Symptomatic renal impairment due to CLL/small lymphocytic lymphoma (SLL) cell infiltration in the kidney tissue is uncommon, and acute kidney injury (AKI) as a presenting feature is rare. In this case report, we describe the case of a patient with AKI caused by CLL/SLL infiltration as a presenting feature. Our report highlights the possibility of kidney injury as the first evident symptom of CLL/SLL. Kidney biopsy is the mainstay in these cases in order to establish a diagnosis. Treatment with zanubrutinib resulted in improved kidney function.

【 授权许可】

Unknown   
Copyright © 2023 Bender, Zeremski, Wiech, Mertens and Gross.