期刊论文详细信息
Frontiers in Physiology | |
Temperature- and chemical-induced neurotoxicity in zebrafish | |
Physiology | |
Chiara Arena1  Carla Cioni1  Mattia Toni1  Gabriella Tedeschi2  | |
[1]Department of Biology and Biotechnologies “Charles Darwin”, Sapienza University, Rome, Italy | |
[2]Department of Veterinary Medicine and Animal Science (DIVAS), Università Degli Studi di Milano, Milano, Italy | |
[3]CRC “Innovation for Well-Being and Environment” (I-WE), Università Degli Studi di Milano, Milano, Italy | |
关键词: neurotoxicity; temperature; zebrafish; proteomic; behaviour; | |
DOI : 10.3389/fphys.2023.1276941 | |
received in 2023-08-13, accepted in 2023-09-22, 发布年份 2023 | |
来源: Frontiers | |
【 摘 要 】
Throughout their lives, humans encounter a plethora of substances capable of inducing neurotoxic effects, including drugs, heavy metals and pesticides. Neurotoxicity manifests when exposure to these chemicals disrupts the normal functioning of the nervous system, and some neurotoxic agents have been linked to neurodegenerative pathologies such as Parkinson’s and Alzheimer’s disease. The growing concern surrounding the neurotoxic impacts of both naturally occurring and man-made toxic substances necessitates the identification of animal models for rapid testing across a wide spectrum of substances and concentrations, and the utilization of tools capable of detecting nervous system alterations spanning from the molecular level up to the behavioural one. Zebrafish (Danio rerio) is gaining prominence in the field of neuroscience due to its versatility. The possibility of analysing all developmental stages (embryo, larva and adult), applying the most common “omics” approaches (transcriptomics, proteomics, lipidomics, etc.) and conducting a wide range of behavioural tests makes zebrafish an excellent model for neurotoxicity studies. This review delves into the main experimental approaches adopted and the main markers analysed in neurotoxicity studies in zebrafish, showing that neurotoxic phenomena can be triggered not only by exposure to chemical substances but also by fluctuations in temperature. The findings presented here serve as a valuable resource for the study of neurotoxicity in zebrafish and define new scenarios in ecotoxicology suggesting that alterations in temperature can synergistically compound the neurotoxic effects of chemical substances, intensifying their detrimental impact on fish populations.【 授权许可】
Unknown
Copyright © 2023 Toni, Arena, Cioni and Tedeschi.
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RO202311143403166ZK.pdf | 2024KB | download |