MicroRNAs, long non-coding RNAs, and circular RNAs and gynecological cancers: focus on metastasis

Frontiers in Oncology

Oncology

Sara Ahmadpour¹  Maryam Mahjoubin-Tehran²  Sarehnaz Aghili³  Michael R. Hamblin⁴  Ameneh Jafari⁵  Ali Rajabi⁶  Arash Raisi⁶  Seyed Saeed Tamehri Zadeh⁷  Marzieh Derakhshan⁸  Aryan Rezaee⁹ 

[1] Biotechnology Department, Faculty of Chemistry, University of Kashan, Kashan, Iran;Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran;Department of Gynecology and Obstetrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, South Africa;Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;School of Medicine, Kashan University of Medical Sciences, Kashan, Iran;Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran;School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;Shahid Beheshti Fertility Clinic, Department of Gynecology and Obsteterics, Isfahan University of Medical Sciences, Isfahan, Iran;Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran;

关键词: gynecological cancer;    metastasis;    invasion;    microRNAs: long non-coding RNAs;    circular RNAs;   

DOI  :  10.3389/fonc.2023.1215194

 received in 2023-05-15, accepted in 2023-08-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

Gynecologic cancer is a significant cause of death in women worldwide, with cervical cancer, ovarian cancer, and endometrial cancer being among the most well-known types. The initiation and progression of gynecologic cancers involve a variety of biological functions, including angiogenesis and metastasis—given that death mostly occurs from metastatic tumors that have invaded the surrounding tissues. Therefore, understanding the molecular pathways underlying gynecologic cancer metastasis is critical for enhancing patient survival and outcomes. Recent research has revealed the contribution of numerous non-coding RNAs (ncRNAs) to metastasis and invasion of gynecologic cancer by affecting specific cellular pathways. This review focuses on three types of gynecologic cancer (ovarian, endometrial, and cervical) and three kinds of ncRNAs (long non-coding RNAs, microRNAs, and circular RNAs). We summarize the detailed role of non-coding RNAs in the different pathways and molecular interactions involved in the invasion and metastasis of these cancers.

【 授权许可】

Unknown   
Copyright © 2023 Rezaee, Ahmadpour, Jafari, Aghili, Zadeh, Rajabi, Raisi, Hamblin, Mahjoubin-Tehran and Derakhshan