CRISPR-Cas-mediated unfolded protein response control for enhancing plant stress resistance

Frontiers in Plant Science

Plant Science

Jae Yong Yoo¹  Tien Van Vu¹  Ki Seong Ko¹  Kyun Oh Lee²  Bich Ngoc Vu²  Ngan Thi Nguyen²  Jae-Yean Kim³ 

[1] Plant Molecular Biology and Biotechnology Research Center (PMBBRC), Gyeongsang National University, Jinju, Republic of Korea;Plant Molecular Biology and Biotechnology Research Center (PMBBRC), Gyeongsang National University, Jinju, Republic of Korea;Division of Applied Life Science (BK21 Four), Gyeongsang National University, Jinju, Republic of Korea;Plant Molecular Biology and Biotechnology Research Center (PMBBRC), Gyeongsang National University, Jinju, Republic of Korea;Division of Applied Life Science (BK21 Four), Gyeongsang National University, Jinju, Republic of Korea;Nulla Bio Inc., Jinju, Republic of Korea;

关键词: endoplasmic reticulum (ER) stress;    unfolded protein response (UPR);    genome editing;    CRISPR-Cas;    crop improvement;   

DOI  :  10.3389/fpls.2023.1271368

 received in 2023-08-02, accepted in 2023-10-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

Plants consistently encounter environmental stresses that negatively affect their growth and development. To mitigate these challenges, plants have developed a range of adaptive strategies, including the unfolded protein response (UPR), which enables them to manage endoplasmic reticulum (ER) stress resulting from various adverse conditions. The CRISPR-Cas system has emerged as a powerful tool for plant biotechnology, with the potential to improve plant tolerance and resistance to biotic and abiotic stresses, as well as enhance crop productivity and quality by targeting specific genes, including those related to the UPR. This review highlights recent advancements in UPR signaling pathways and CRISPR-Cas technology, with a particular focus on the use of CRISPR-Cas in studying plant UPR. We also explore prospective applications of CRISPR-Cas in engineering UPR-related genes for crop improvement. The integration of CRISPR-Cas technology into plant biotechnology holds the promise to revolutionize agriculture by producing crops with enhanced resistance to environmental stresses, increased productivity, and improved quality traits.

【 授权许可】

Unknown   
Copyright © 2023 Vu, Vu, Yoo, Nguyen, Ko, Kim and Lee