Bovine reproductive immunoinfertility: pathogenesis and immunotherapy

Frontiers in Veterinary Science

Veterinary Science

Dipti Nain¹  Raju Kumar Dewry¹  Nadeem Shah¹  Manisha Sethi¹  Vinod Kumar Gupta¹  Tushar Kumar Mohanty¹  Mukesh Bhakat¹  Mahak Singh²  Rupali Rautela³  Rahul Katiyar⁴  Sourabh Deori⁴ 

[1] Artificial Breeding Research Centre (ABRC), ICAR-National Dairy Research Institute, Karnal, India;CAR Research Complex for NEH Region, Nagaland Centre, Medziphema, India;CAR-Central Institute for Research on Buffaloes, Hisar, India;Division of Animal and Fisheries Sciences, ICAR Research Complex for NEH Region, Umiam, Meghalaya, India;

关键词: cattle;    endometritis;    immunoinfertility;    immunomodulators;    LPS;   

DOI  :  10.3389/fvets.2023.1248604

 received in 2023-06-27, accepted in 2023-09-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

Infertility is one of the primary factors for cattle reproduction in the present scenario. Reproduction-related immunoinfertility mainly involves immunization against the antigens related to reproductive hormones (LHRH, GnRH, Gonadal steroids, PGF2α and oxytocin), spermatozoa, seminal plasma and ovum. Anovulation, delayed ovulation, sperm immobilization, failure of fertilization, prolonged uterine involution, extended calving interval, prolonged post-partum estrus and reduced conception rate could be a result of immunoinfertility that occur due to the blockage of receptor site by antibodies formed against hormones, sperm and ovum. Immunoinfertility can be treated in the animal by giving sexual rest to females, by using various reproductive technologies such as in-vitro fertilization, gamete intra fallopian tube transfer, and intracytoplasmic sperm injection, sperm washing and by treating the animals with immunomodulators such as LPS, Oyster glycogen, etc. This review summarizes the different causes of bovine reproductive immunoinfertility and amelioration strategies to overcome it.

【 授权许可】

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Copyright © 2023 Gupta, Mohanty, Bhakat, Dewry, Katiyar, Nain, Shah, Sethi, Rautela, Singh and Deori.