Bacterial outer membrane vesicles as drug delivery carrier for photodynamic anticancer therapy

Frontiers in Chemistry

Chemistry

ZunZhen Zhou¹  Yuan Jiang¹  Chongzhi Liu¹  Limei Wang²  Chun Li³ 

[1] Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China;Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China;Department of Rehabilitation Medicine, The Third Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China;Department of Rehabilitation Medicine, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China;

关键词: photodynamic therapy;    photosensitizers;    drug delivery carrier;    nanoparticles;    outer membrane vesicles;   

DOI  :  10.3389/fchem.2023.1284292

 received in 2023-08-28, accepted in 2023-10-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

Photodynamic Therapy (PDT) is an effective tumor treatment strategy that not only induces photocytotoxicity to kill tumor cells directly but also activates the immune system in the body to generate tumor-specific immunity, preventing cancer metastasis and recurrence. However, some limitations of PDT limit the therapeutic efficacy in deep tumors. Previous studies have used different types of nanoparticles (NPs) as drug carriers of photosensitizers (PSs) to overcome the shortcomings of PDT and improve therapeutic efficacy. Among them, bacterial outer membrane vesicles (OMVs) have natural advantages as carriers for PS delivery. In addition to the targeted delivery of PSs into tumor cells, their unique immunogenicity helps them to serve as immune adjuvants to enhance the PDT-induced immune effect, providing new ideas for photodynamic anticancer therapy. Therefore, in this review, we will introduce the biogenesis and anticancer functions of OMVs and the research on them as drug delivery carriers in PDT. Finally, we also discuss the challenges and prospects of OMVs as a versatile drug delivery carrier for photodynamic anticancer therapy.

【 授权许可】

Unknown   
Copyright © 2023 Jiang, Zhou, Liu, Wang and Li.