Efficacy of ferulic acid in the treatment of acute ischemic stroke injury in rats: a systematic review and meta-analysis

Frontiers in Pharmacology

Pharmacology

Meiqi Tang¹  Zhuqing Jin²  Xiuzhen Xie³  Yingqi Xu⁴  Pingping Su⁵  Jiashan Wang⁵ 

[1]Department of Chemistry, Zhejiang University, Hangzhou, China

[2]School of Basic Medicine Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China

[3]The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China

[4]The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China

[5]The Third School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China

关键词: ferulic acid;    acute ischemic stroke injury;    excitotoxicity;    inflammatory response;    apoptosis;    meta-analysis;   

DOI  :  10.3389/fphar.2023.1278036

 received in 2023-08-15, accepted in 2023-10-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

Background: Intravenous thrombolysis is commonly used in the treatment of acute ischemic stroke damage. The existing thrombolytic drugs still suffer significant shortcomings, including a limited fibrin specificity and bleeding complications. Ferulic acid can directly bind the key thrombus enzymes and target to blood clots, suggesting its thrombolytic potency that may be beneficial with thrombolytic potency for the treatment of acute ischemic stroke damage.Objective: The purpose of this systematic review and meta-analysis was to evaluate the efficacy of ferulic acid in the treatment of acute ischemic stroke injury in rats and its potential mechanism of action.Materials and methods: We conducted a literature search in six databases, including CNKI, up to July 2023.Results: Sixteen trials were included in the meta-analysis, which demonstrated that ferulic acid significantly reduced infarct size, neurological deficit score, apoptosis index, cleaved caspase-3, and cytochrome C levels (all p < 0.05). In addition, ferulic acid significantly increased the levels of phosphorylated Akt, mitochondrial Bcl-xL/Bax, phosphorylated astrocyte PEA15, hippocampal calcium binding protein, and mitochondrial Bcl-2/Bax ratio (all p < 0.05).Conclusion: This study demonstrates that ferulic acid protects against acute ischemic stroke injury in rats by inhibiting ischemia-induced excitotoxicity, inflammatory response, and apoptosis.

【 授权许可】

Unknown   
Copyright © 2023 Wang, Tang, Xie, Xu, Su and Jin.