Genome-wide Mendelian randomization identifies putatively causal gut microbiota for multiple peptic ulcer diseases

Frontiers in Immunology

Immunology

Yucheng Hou¹  Xinyi Feng²  Yizhang Zhu³  Jingwei Zhao⁴  Yong Zhang⁴  Wei Gong⁴  Ziyi Yang⁴  Tianyi Xie⁵ 

[1] Department of Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China;Department of Gastroenterology, Wuzhong People’s Hospital of Suzhou, Suzhou, China;Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China;Department of General Surgery, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China;Shanghai Key Laboratory of Biliary Tract Disease Research, Shanghai, China;Laboratory of Medical Science, School of Medicine, Nantong University, Nantong, Jiangsu, China;

关键词: Mendelian randomization;    gut microbiota;    peptic ulcer;    causal relationship;    genus;   

DOI  :  10.3389/fimmu.2023.1260780

 received in 2023-07-18, accepted in 2023-09-04,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveThe pathogenesis of peptic ulcer diseases (PUDs) involves multiple factors, and the contribution of gut microbiota to this process remains unclear. While previous studies have associated gut microbiota with peptic ulcers, the precise nature of the relationship, whether causal or influenced by biases, requires further elucidation.DesignThe largest meta-analysis of genome-wide association studies was conducted by the MiBioGen consortium, which provided the summary statistics of gut microbiota for implementation in the Mendelian randomization (MR) analysis. Summary statistics for five types of PUDs were compiled using the FinnGen Consortium R8 release data. Various statistical techniques, including inverse variance weighting (IVW), MR-Egger, weighted median (WM), weighted mode, and simple mode, were employed to assess the causal relationships between gut microbiota and these five PUDs.ResultIn the intestinal microbiome of 119 known genera, we found a total of 14 causal associations with various locations of PUDs and reported the potential pathogenic bacteria of Bilophila et al. Among them, four had causal relationships with esophageal ulcer, one with gastric ulcer, three with gastroduodenal ulcer, four with duodenal ulcer, and two with gastrojejunal ulcer.ConclusionIn this study, the pathogenic bacterial genera in the gut microbiota that promote the occurrence of PUDs were found to be causally related. There are multiple correlations between intestinal flora and PUDs, overlapping PUDs have overlapping associated genera. The variance in ulcer-related bacterial genera across different locations underscores the potential influence of anatomical locations and physiological functions.

【 授权许可】

Unknown   
Copyright © 2023 Zhao, Hou, Xie, Zhu, Feng, Zhang, Yang and Gong