Prevalence of aortic aneurysms and dissections in patients with systemic vessel aneurysms and dissections; matched case-control study using a national sample cohort

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Jihye Song¹  Yong Cheol Lim¹  Do Jung Kim² 

[1] Department of Neurosurgery, Ajou University School of Medicine, Ajou University Hospital, Suwon, Republic of Korea;Department of Thoracic and Cardiovascular Surgery, Ajou University School of Medicine, Ajou University Hospital, Suwon, Republic of Korea;

关键词: aneurysm;    aortic disease;    aortic dissection;    aortic aneurysm;    peripheral artery disease;   

DOI  :  10.3389/fcvm.2023.1266430

 received in 2023-07-24, accepted in 2023-10-11,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveAneurysms in systemic arteries are rare, and little is known about their relationship with aortic aneurysms. In this study, we aimed to evaluate the prevalence of aortic aneurysms and dissections (AAD) in patients with other systemic vessel aneurysms and dissections (OVAD) and identify their potential risk factors.MethodsThis cross-sectional study used a nationwide representative cohort sample from the Korea National Health Insurance Service-National Sample Cohort database. We defined OVAD as systemic vessel aneurysms and dissections excluding intracranial and aortic dissections and aneurysms. With a total of 690 OVAD patients and 2,760 non-OVAD matched controls, we investigated the prevalence of AAD in patients with OVAD and potential risk factors for their concurrence using the χ2 test and logistic regression.ResultsThe prevalence of AAD in patients with OVAD was 10.6% (73/690) and 0.3% (9/2,760) in patients with non-OVAD. The adjusted odds ratio (OR) for having concurrent AAD with OVAD was 37.56 (95% CI: 18.29–77.12, p < 0.001) after stratification by sex, age, income, region of residence and after adjustment for hypertension, diabetes mellitus, dyslipidemia, and extent of disability. The adjusted ORs of AAD were significantly higher in females [adjusted OR = 47.63 (95% CI: 10.72–211.55)], and individuals aged ≥60 years [adjusted OR = 28.18 (95% CI: 13.42–59.17)], as well as those without hypertension [adjusted OR = 95.44 (95% CI: 18.21–500.23)], diabetes mellitus [adjusted OR = 46.39 (95% CI: 18.85–114.17)], without dyslipidemia [adjusted OR = 60.99 (95% CI: 20.83–178.56), p < 0.001 for all]. The prevalence of AAD significantly differed by according to specific sites of OVAD in carotid artery, upper extremity artery, iliac artery, lower extremity artery, and splanchnic artery (p < 0.001 for all).ConclusionsThe prevalence of AAD in patients with OVAD was 37.56 times higher than that in the matched population. We may approach aneurysms as systemic diseases and further investigations of pathophysiology would help to clarify the relationships between AAD and OVAD.

【 授权许可】

Unknown   
© 2023 Song, Lim and Kim.