The shared genetic risk factors between Tourette syndrome and obsessive-compulsive disorder

Frontiers in Neurology

Neurology

Yasser Saeed Khan¹  Foysal Ahammad²  Farhan Mohammad²  Mohamed Adil Shah Khoodoruth³ 

[1] Child and Adolescent Mental Health Service, Hamad Medical Corporation, Doha, Qatar;College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar;College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar;Child and Adolescent Mental Health Service, Hamad Medical Corporation, Doha, Qatar;

关键词: Tourette sydrome;    obsessive – compulsive disorder;    shared genetic factors;    neurogenetics;    neuropsychiatic genetics;    genetics;    epigenetics;    genomics;   

DOI  :  10.3389/fneur.2023.1283572

 received in 2023-09-14, accepted in 2023-09-25,  发布年份 2023

来源: Frontiers

【 摘 要 】

Tourette syndrome (TS) and obsessive-compulsive disorder (OCD) are two neuropsychiatric disorders that frequently co-occur. Previous evidence suggests a shared genetic diathesis underlying the comorbidity of TS and OCD. This review aims to comprehensively summarize the current literature on the genetic factors linked with TS and its comorbidities, with a focus on OCD. Family studies, linkage analysis, cytogenetic studies, and genome-wide association studies (GWAS) have played a pivotal role in identifying common and rare genetic variants connected with TS and OCD. Although the genetic framework of TS and OCD is complex and multifactorial, several susceptibility loci and candidate genes have been identified that might play a crucial role in the pathogenesis of both disorders. Additionally, post-infectious environmental elements have also been proposed to contribute to the development of TS-OCD, although the dynamics between genetic and environmental factors is not yet fully understood. International collaborations and studies with well-defined phenotypes will be crucial in the future to further elucidate the genetic basis of TS and OCD and to develop targeted therapeutic strategies for individuals suffering from these debilitating conditions.

【 授权许可】

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Copyright © 2023 Khoodoruth, Ahammad, Khan and Mohammad.