Non-tuberculous mycobacterial disease: progress and advances in the development of novel candidate and repurposed drugs

Frontiers in Cellular and Infection Microbiology

Cellular and Infection Microbiology

Xia Yu¹  Yuzhen Gu¹  Hairong Huang¹  Wenjuan Nie² 

[1] National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory on Drug-Resistant Tuberculosis, Beijing Chest Hospital, Capital Medical University, Beijing, China;Tuberculosis Department, Beijing Chest Hospital, Capital Medical University, Beijing, China;

关键词: NTM (nontuberculous mycobacteria);    antibiotic;    inhibitor;    NTM pulmonary disease;    treatment;   

DOI  :  10.3389/fcimb.2023.1243457

 received in 2023-06-20, accepted in 2023-09-11,  发布年份 2023

来源: Frontiers

【 摘 要 】

Non-tuberculous mycobacteria (NTM) are opportunistic pathogens that can infect all body tissues and organs. In particular, the lungs are the most commonly involved organ, with NTM pulmonary diseases causing serious health issues in patients with underlying lung disease. Moreover, NTM infections have been steadily increasing worldwide in recent years. NTM are also naturally resistant to many antibiotics, specifically anti-tuberculosis (anti-TB) drugs. The lack of drugs targeting NTM infections and the increasing drug resistance of NTM have further made treating these mycobacterial diseases extremely difficult. The currently recommended NTM treatments rely on the extended indications of existing drugs, which underlines the difficulties of new antibiotic discovery against NTM. Another challenge is determining which drug combinations are most effective against NTM infection. To a certain extent, anti-NTM drug development depends on using already available antibiotics and compounds. Here, we aimed to review new antibiotics or compounds with good antibacterial activity against NTM, focusing on their mechanisms of action, in vitro and in vivo antibacterial activities.

【 授权许可】

Unknown   
Copyright © 2023 Gu, Nie, Huang and Yu

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