Short term effect of tetrahydrocurcumin on adipose angiogenesis in very high-fat diet-induced obesity mouse model

Frontiers in Nutrition

Nutrition

Narongsuk Munkong¹  Natwadee Poomipark²  Pholawat Tingpej³  Chatchawan Changtam⁴  Bhornprom Yoysungnoen⁵  Umarat Srisawat⁵  Nattapon Sookprasert⁵  Naphatsanan Duansak⁵  Pritsana Piyabhan⁵  Nakorn Mathuradavong⁵ 

[1] Department of Pathology, School of Medicine, University of Phayao, Phayao, Thailand;Division of Biochemistry, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand;Division of Microbiology and Immunology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand;Division of Physical Science, Faculty of Science and Technology, Huachiew Chalermprakiet University, Samutprakarn, Thailand;Division of Physiology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand;

关键词: adipose angiogenesis;    obesity;    vascular endothelial growth factor (VEGF);    matrix metalloproteinase-2 (MMP-2);    matrix metalloproteinase-9 (MMP-9);    tumor necrosis factor-alpha (TNF-α);   

DOI  :  10.3389/fnut.2023.1221935

 received in 2023-05-17, accepted in 2023-09-26,  发布年份 2023

来源: Frontiers

【 摘 要 】

Tetrahydrocurcumin (THC) has been shown to possess anti-angiogenic activities. This study aims to investigate the effects of THC on adipose angiogenesis and expression of angiogenic factors that occurs in 60% high-fat diet-induced obese mice. Male ICR mice were randomly divided into 3 groups: mice fed with a low-fat diet (LFD group); mice fed with very high fat diet (VHFD group), and mice fed with VHFD supplemented with THC (300 mg/kg/day orally) (VHFD+THC treated group) for 6 weeks. Body weight (BW), food intake, fasting blood sugar (FBS), lipid profiles and visceral fats weight (VF) were measured. The microvascular density (MVD), TNF-α, VEGF, MMP-2, and MMP-9 expressions were evaluated. The VHFD group had significantly increased total cholesterol, triglyceride, food intake, BW, VF, VF/BW ratio, adipocyte size and the number of crown-liked structures as compared to LFD group. THC supplementation markedly reduced these parameters and adipocyte hypertrophy and inflammation in white adipose tissues. MVD, TNF-α, VEGF, MMP-2, and MMP-9 were over-expressed in the VHFD group. However, THC supplementation decreased MVD and reduced expression of TNF-α, VEGF, MMP-2, and MMP-9. In conclusion, THC suppressed angiogenesis in adipose tissue by the downregulation of TNF-α, VEGF, MMP-2, and MMP-9. With its effects on lipid metabolism as well as on food consumption, THC could contribute to lower visceral fat and body weight. Overall, our study demonstrated the potential benefit of THC in mitigating obesity and associated metabolic disorders along with elucidated the suppression of adipose angiogenesis as one of its underlying mechanisms.

【 授权许可】

Unknown   
Copyright © 2023 Yoysungnoen, Srisawat, Piyabhan, Sookprasert, Duansak, Mathuradavong, Poomipark, Munkong, Tingpej and Changtam.