Connections between serum Trimethylamine N-Oxide (TMAO), a gut-derived metabolite, and vascular biomarkers evaluating arterial stiffness and subclinical atherosclerosis in children with obesity

Frontiers in Endocrinology

Endocrinology

Oana-Alexandra Velea-Barta¹  Andreea Borlea²  Dana Stoian²  Denisa Pescari³  Monica Simina Mihuta⁴  Cristina Mihaela Roi⁴  Ioana Mozos⁵  Corina Paul⁶ 

[1] 3rd Department of Odontotherapy and Endodontics, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania;Center of Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania;2nd Department of Internal Medicine, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania;Department of Doctoral Studies, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania;Department of Doctoral Studies, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania;Center of Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania;Department of Functional Sciences—Pathophysiology, Center for Translational Research and Systems Medicine, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania;Department of Pediatrics, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania;

关键词: arterial stiffness;    atherosclerosis;    cardiovascular risk;    carotid intima-media thickness;    childhood obesity;    high blood pressure;    pulse wave velocity;    TMAO;   

DOI  :  10.3389/fendo.2023.1253584

 received in 2023-07-05, accepted in 2023-09-12,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionChildhood obesity leads to early subclinical atherosclerosis and arterial stiffness. Studying biomarkers like trimethylamine N-oxide (TMAO), linked to cardio-metabolic disorders in adults, is crucial to prevent long-term cardiovascular issues.MethodsThe study involved 70 children aged 4 to 18 (50 obese, 20 normal-weight). Clinical examination included BMI, waist measurements, puberty stage, the presence of acanthosis nigricans, and irregular menstrual cycles. Subclinical atherosclerosis was assessed by measuring the carotid intima-media thickness (CIMT), and the arterial stiffness was evaluated through surrogate markers like the pulse wave velocity (PWV), augmentation index (AIx), and peripheral and central blood pressures. The blood biomarkers included determining the values of TMAO, HOMA-IR, and other usual biomarkers investigating metabolism.ResultsThe study detected significantly elevated levels of TMAO in obese children compared to controls. TMAO presented positive correlations to BMI, waist circumference and waist-to-height ratio and was also observed as an independent predictor of all three parameters. Significant correlations were observed between TMAO and vascular markers such as CIMT, PWV, and peripheral BP levels. TMAO independently predicts CIMT, PWV, peripheral BP, and central SBP levels, even after adding BMI, waist circumference, waist-to-height ratio, puberty development and age in the regression model. Obese children with high HOMA-IR presented a greater weight excess and significantly higher vascular markers, but TMAO levels did not differ significantly from the obese with HOMA-IR

【 授权许可】

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Copyright © 2023 Mihuta, Paul, Borlea, Roi, Pescari, Velea-Barta, Mozos and Stoian