MFPPDB: a comprehensive multi-functional plant peptide database

Frontiers in Plant Science

Plant Science

Hongwei Wu¹  Yu Gao¹  Ke Li²  Yaozu Yang³  Wei Tong⁴ 

[1] School of Information and Computer, Anhui Agricultural University, Hefei, China;School of Information and Computer, Anhui Agricultural University, Hefei, China;Information Materials and Intelligent Sensing Laboratory of Anhui Province, Anhui University, Hefei, Anhui, China;Anhui Provincial Engineering Laboratory for Beidou Precision Agriculture Information, Anhui Agricultural University, Hefei, Anhui, China;School of Information and Computer, Anhui Agricultural University, Hefei, China;Information Materials and Intelligent Sensing Laboratory of Anhui Province, Anhui University, Hefei, Anhui, China;State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, Anhui, China;State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, Anhui, China;

关键词: multi-functional;    therapeutic peptide;    plant;    database;    peptidomes;   

DOI  :  10.3389/fpls.2023.1224394

 received in 2023-05-17, accepted in 2023-09-29,  发布年份 2023

来源: Frontiers

【 摘 要 】

Plants produce a wide range of bioactive peptides as part of their innate defense mechanisms. With the explosive growth of plant-derived peptides, verifying the therapeutic function using traditional experimental methods are resources and time consuming. Therefore, it is necessary to predict the therapeutic function of plant-derived peptides more effectively and accurately with reduced waste of resources and thus expedite the development of plant peptides. We herein developed a repository of plant peptides predicted to have multiple therapeutic functions, named as MFPPDB (multi-functional plant peptide database). MFPPDB including 1,482,409 single or multiple functional plant origin therapeutic peptides derived from 121 fundamental plant species. The functional categories of these therapeutic peptides include 41 different features such as anti-bacterial, anti-fungal, anti-HIV, anti-viral, and anti-cancer. The detailed physicochemical information of these peptides was presented in functional search and physicochemical property search module, which can help users easily access the peptide information by the plant peptide species, ID, and functions, or by their peptide ID, isoelectric point, peptide sequence, and molecular weight through web-friendly interface. We further matched the predicted peptides to nine state-of-the-art curated functional peptide databases and found that at least 293,408 of the peptides possess functional potentials. Overall, MFPPDB integrated a massive number of plant peptides have single or multiple therapeutic functions, which will facilitate the comprehensive research in plant peptidomics. MFPPDB can be freely accessed through http://124.223.195.214:9188/mfppdb/index.

【 授权许可】

Unknown   
Copyright © 2023 Yang, Wu, Gao, Tong and Li