The role of the thyroid in polycystic ovary syndrome

Frontiers in Endocrinology

Endocrinology

Qingling Ren¹  Huanhuan Fan¹  Ganxiu Deng²  Limei Li³  Zhejin Sheng⁴ 

[1] Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China;Department of Respiratory and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine, Tongji University, Shanghai, China;Research Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;School of Life Science and Technology, Tongji University, Shanghai, China;

关键词: pcos;    thyroid;    metabolic abnormalities;    reproductive disorders;    potential mechanism;   

DOI  :  10.3389/fendo.2023.1242050

 received in 2023-06-18, accepted in 2023-09-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disease in women of childbearing age and can cause metabolic disorder, infertility, and increased anxiety and depression; as a result, it can seriously affect the physical and mental health of fertile women. PCOS is a highly clinically heterogeneous disease with unclear etiology and pathogenesis, which increases the difficulty of treatment. The thyroid gland has complex regulatory effects on metabolism, reproduction, and emotion, and produces hormones that act on almost all cells of the human body. The clinical manifestations of PCOS are similar to some thyroid diseases. Furthermore, some thyroid diseases, such as subclinical hypothyroidism (SCH), not only increase the incidence rate of PCOS, but also exacerbate its associated metabolic abnormalities and reproductive disorders. Interestingly, PCOS also increases the incidence of some thyroid diseases. However, the role of the thyroid in PCOS remains unclear. This review is intended to thoroughly explore the critical role of the thyroid in PCOS by summarizing the comorbidity of PCOS and thyroid diseases and their combined role in metabolic disorders, related metabolic diseases, and reproductive disorders; and by analyzing the potential mechanism through which the thyroid influences the development and progression of PCOS and its symptoms. We hope this review will provide a valuable reference for the role of the thyroid in PCOS.

【 授权许可】

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Copyright © 2023 Fan, Ren, Sheng, Deng and Li