Invasion of the bucco-mandibular space by oral squamous cell carcinoma: histopathological analysis of invasion pattern

Frontiers in Oncology

Oncology

Junichiro Sakamoto¹  Masahiko Miura¹  R. Shane Tubbs²  Kou Kayamori³  Tohru Ikeda³  Joe Iwanaga⁴  Takeshi Kuroshima⁵  Naoto Nishii⁵  Yu Oikawa⁵  Hirofumi Tomioka⁵  Hideaki Hirai⁵  Takuma Kugimoto⁵  Hiroyuki Harada⁵  Yasuyuki Michi⁵ 

[1] Department of Dental Radiology and Radiation Oncology, Division of Oral Health Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan;Department of Neurosurgery, Tulane Center for Clinical Neurosciences, Tulane University School of Medicine, New Orleans, LA, United States;Department of Oral Pathology, Division of Oral Health Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan;Department of Oral and Maxillofacial Anatomy, Division of Oral Health Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan;Department of Neurosurgery, Tulane Center for Clinical Neurosciences, Tulane University School of Medicine, New Orleans, LA, United States;Department of Oral and Maxillofacial Surgical Oncology, Division of Oral Health Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan;

关键词: bucco-mandibular space;    oral squamous cell carcinoma;    gingiva-buccal complex;    mandible;    buccinator muscle;   

DOI  :  10.3389/fonc.2023.1168376

 received in 2023-02-17, accepted in 2023-09-15,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundThis study aimed to determine the patterns of invasion of oral squamous cell carcinoma (OSCC) into the bucco-mandibular space (BMS) using detailed histopathological analysis and to assess clinical outcomes.MethodsPatients with OSCC who underwent segmental mandibulectomy or hemi-mandibulectomy combined with resection of the BMS between 2012 and 2021 were included. The invasions of the BMS were classified into three patterns. Pattern A was defined as a horizontal invasion, Pattern B as a vertical invasion, and Pattern C as an expansive invasion.ResultsIn total, 109 patients were reviewed. Of these 109 patients, the primary tumor affected the lower gingiva in 78 patients, the buccal mucosa in 18 patients, and was a primary intraosseous carcinoma of the mandible in 13 patients. Invasion of the BMS was significantly associated with a higher pathological T stage, positive/close margins, and lower disease-free survival (DFS) rates. The DFS rates were 86.7% and 66.0% in the BMS non-invasion and invasion groups, respectively. The DFS rates for each type of invasion were 82.1% for Pattern A, 67.4% for Pattern B, and 48.0% for Pattern C (P=0.277).ConclusionPatients with BMS invasion have a poorer prognosis than those without invasion of the BMS. Therefore, adjuvant therapy is necessary, especially in Patterns B and C. Evaluation of preoperative BMS invasion patterns is important for predicting the prognosis of OSCC.

【 授权许可】

Unknown   
Copyright © 2023 Kugimoto, Nishii, Oikawa, Kuroshima, Hirai, Tomioka, Michi, Kayamori, Sakamoto, Iwanaga, Tubbs, Ikeda, Miura and Harada