Type 1 diabetes, glycemic traits, and risk of dental caries: a Mendelian randomization study

Frontiers in Genetics

Genetics

Qin Ye¹  Jing Hu¹  Ze-Yue Ou-Yang¹  Xiao-Lin Su¹  Ning-Xin Chen¹  Li Tan¹  Meng-Mei Zhong¹  Qiong Liu¹  Jie Zhao¹  Min-Yuan Wang¹  Ya-Qiong Zhao¹  Qian Zhang¹  Yao Feng¹  Marie Aimee Dusenge¹  Hui Yuan¹  Yun-Zhi Feng²  Yue Guo³ 

[1] Department of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China;[e-mail];null;

关键词: Mendelian randomization analysis;    diabetes mellitus;    type 1;    glycemic traits;    dental caries;    multidisciplinary intervention;   

DOI  :  10.3389/fgene.2023.1230113

 received in 2023-06-20, accepted in 2023-09-25,  发布年份 2023

来源: Frontiers

【 摘 要 】

Background: Regarding past epidemiological studies, there has been disagreement over whether type 1 diabetes (T1DM) is one of the risk factors for dental caries. The purpose of this study was to determine the causative links between genetic susceptibility to T1DM, glycemic traits, and the risk of dental caries using Mendelian randomization (MR) approaches.Methods: Summary-level data were collected on genome-wide association studies (GWAS) of T1DM, fasting glucose (FG), glycated hemoglobin (HbA1c), fasting insulin (FI), and dental caries. MR was performed using the inverse-variance weighting (IVW) method, and sensitivity analyses were conducted using the MR-Egger method, weighted median, weighted mode, replication cohort, and multivariable MR conditioning on potential mediators.Results: The risk of dental caries increased as a result of genetic susceptibility to T1DM [odds ratio (OR) = 1.044; 95% confidence interval (CI) = 1.015–1.074; p = 0.003], with consistent findings in the replication cohort. The relationship between T1DM and dental caries was stable when adjusted for BMI, smoking, alcohol intake, and type 2 diabetes (T2DM) in multivariable MR. However, no significant correlations between the risk of dental caries and FG, HbA1c, or FI were found.Conclusion: These results indicate that T1DM has causal involvement in the genesis of dental caries. Therefore, periodic reinforcement of oral hygiene instructions must be added to the management and early multidisciplinary intervention of T1DM patients, especially among adolescents and teenagers, who are more susceptible to T1DM.

【 授权许可】

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Copyright © 2023 Tan, Zhong, Zhao, Zhao, Dusenge, Feng, Ye, Hu, Ou-Yang, Chen, Su, Zhang, Liu, Yuan, Wang, Feng and Guo.