Case report: Ghost cell odontogenic carcinoma in a dog: diagnostics and surgical outcome

Frontiers in Veterinary Science

Veterinary Science

Chun-Geun Kim¹  Ga-Won Lee²  Hyun Sil Kim³  Seung-Yong Han³  Dawool Han³  Hee-Myung Park⁴ 

[1] Dentistry and Oral Surgery Service, Evichi Veterinary Dental Hospital, Seoul, Republic of Korea;Department of Companion Animal Industry, College of Health and Welfare, Dongshin University, Naju, Republic of Korea;Department of Oral Pathology, Oral Cancer Research Institute, Yonsei University College of Dentistry, Seoul, Republic of Korea;Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea;

关键词: ghost cell odontogenic carcinoma (GCOC);    dog;    odontogenic carcinoma;    oral tumor;    ghost cell;   

DOI  :  10.3389/fvets.2023.1267222

 received in 2023-07-26, accepted in 2023-09-18,  发布年份 2023

来源: Frontiers

【 摘 要 】

A 6 year-old spayed female Poodle presented with a mandibular mass. Radiographic examination revealed osteolysis from the right mandibular canine to the fourth premolar, along with horizontal bone loss and dorsal displacement of the right mandibular first and second premolars. Skull cone beam computed tomography revealed osteolysis at the level of the right mandibular canine and fourth premolar. A destructive bone lesion was observed in the apical area of the right mandibular canine, with mass invasion of the interradicular bone of the right mandibular first molar near the mandibular canal. Consequently, unilateral total mandibulectomy and skin flap surgery were performed. Histopathological examination revealed poorly demarcated and infiltrative neoplastic epithelial cells that formed small islands and trabeculae. Neoplastic cells exhibited the malignant features of cytological atypia and high mitotic activity. Furthermore, the neoplastic epithelial cells frequently showed ghost cell changes and were diagnosed as ghost cell odontogenic carcinoma (GCOC). The dog was followed up for 1 year, during which no severe complications or local recurrence was observed, except for slight mandibular drift, tongue protrusion, and drooling. This case report describes the clinical features, diagnostic imaging, and histologic features of an unreported GCOC in a dog and the favorable outcome following surgical resection.

【 授权许可】

Unknown   
Copyright © 2023 Kim, Lee, Kim, Han, Han and Park.