Baroreflex sensitivity following acute upper-body exercise in the cold among stable coronary artery disease patients

Frontiers in Physiology

Physiology

Kalle Pikkarainen¹  Jouni J. K. Jaakkola²  Tiina M. Ikäheimo³  Heidi E. Hintsala⁴  Craig G. Crandall⁵  Arto J. Hautala⁶  Rasmus I. P. Valtonen⁷  Juha Perkiömäki⁷  Antti Kiviniemi⁷  Mikko P. Tulppo⁷ 

[1] Center for Environmental and Respiratory Health Research, Research Unit of Population Health, University of Oulu, Oulu, Finland;Center for Environmental and Respiratory Health Research, Research Unit of Population Health, University of Oulu, Oulu, Finland;Medical Research Center, University of Oulu, Oulu University Hospital, Oulu, Finland;Center for Environmental and Respiratory Health Research, Research Unit of Population Health, University of Oulu, Oulu, Finland;Medical Research Center, University of Oulu, Oulu University Hospital, Oulu, Finland;Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway;Centria University of Applied Sciences, Kokkola, Finland;Department of Internal Medicine, Texas Health Presbyterian Hospital, Institute for Exercise and Environmental Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States;Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland;Research Unit of Biomedicine and Internal Medicine, Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland;

关键词: autonomic nervous system;    baroreflex;    blood pressure variability;    cold;    exercise;    upper-body exercise;    coronary artery disease;   

DOI  :  10.3389/fphys.2023.1184378

 received in 2023-03-11, accepted in 2023-09-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

Background: A cold environment and exercise separately affect the autonomic nervous system (ANS), baroreflex sensitivity (BRS), and blood pressure variability (BPV) but their combined effects on post-exercise recovery are not known. Our cross-over trial examined these responses following upper-body static and dynamic exercise performed in a cold and neutral environment in patients with coronary artery disease (CAD).Methods: 20 patients with stable coronary artery disease performed both graded static (10%–30% of maximal voluntary contraction) and dynamic (light, moderate and high perceived intensity) upper-body exercise at −15°C and +22°C for 30 min. Electrocardiogram and continuous blood pressure were measured to compute post-exercise (10 and 30 min after exercise) spectral powers of heart rate (HR), blood pressure variability and BRS at low (0.04–0.15 Hz) and high (0.15–0.4 Hz) frequencies.Results: Static upper-body exercise performed in a cold environment increased post-exercise high frequency (HF) spectral power of heart rate (HF RR) (p < 0.001) and reduced heart rate (p = 0.001) and low-to-high frequency (LF/HF) ratio (p = 0.006) more than in a neutral environment. In addition, post-exercise mean BRS (p = 0.015) and high frequency BRS (p = 0.041) increased more following static exercise in the cold than in a neutral environment. Dynamic upper-body exercise performed in a cold environment reduced post-exercise HF BRS (p = 0.019) and systolic blood pressure (p = 0.003).Conclusion: Static upper-body exercise in the cold increased post-exercise BRS and overall vagal activity but without reduced systolic blood pressure. Dynamic upper-body exercise in the cold reduced post-exercise vagal BRS but did not affect the other parameters. The influence of cold exposure on post-exercise autonomic and cardiovascular responses following static upper-body exercise require further studies. This information helps understanding why persons with cardiovascular diseases are vulnerable to low environmental temperature. ClinicalTrials.gov: NCT02855905 (04/08/2016).

【 授权许可】

Unknown   
Copyright © 2023 Pikkarainen, Valtonen, Hintsala, Kiviniemi, Crandall, Perkiömäki, Hautala, Tulppo, Jaakkola and Ikäheimo.