Advances in Mesenchymal stem cells regulating macrophage polarization and treatment of sepsis-induced liver injury

Frontiers in Immunology

Immunology

Lihong Yang¹  Yuhao Chen¹  Xihong Li¹ 

[1] Department of Emergency Medicine, West China Second Hospital of Sichuan University, Sichuan, China;Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Sichuan, China;

关键词: mesenchymal stem cells (MSCs);    sepsis;    liver injury;    kupffer cells;    macrophage polarization;   

DOI  :  10.3389/fimmu.2023.1238972

 received in 2023-07-23, accepted in 2023-10-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

Sepsis is a syndrome of dysregulated host response caused by infection, which leads to life-threatening organ dysfunction. It is a familiar reason of death in critically ill patients. Liver injury frequently occurs in septic patients, yet the development of targeted and effective treatment strategies remains a pressing challenge. Macrophages are essential parts of immunity system. M1 macrophages drive inflammation, whereas M2 macrophages possess anti-inflammatory properties and contribute to tissue repair processes. Mesenchymal stem cells (MSCs), known for their remarkable attributes including homing capabilities, immunomodulation, anti-inflammatory effects, and tissue regeneration potential, hold promise in enhancing the prognosis of sepsis-induced liver injury by harmonizing the delicate balance of M1/M2 macrophage polarization. This review discusses the mechanisms by which MSCs regulate macrophage polarization, alongside the signaling pathways involved, providing an idea for innovative directions in the treatment of sepsis-induced liver injury.

【 授权许可】

Unknown   
Copyright © 2023 Chen, Yang and Li