Cortical circuit dynamics underlying motor skill learning: from rodents to humans

Frontiers in Molecular Neuroscience

Molecular Neuroscience

Emily Kogan¹  Ju Lu²  Yi Zuo² 

[1] Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA, United States;null;

关键词: motor learning;    cross-species;    primary motor cortex;    neuron;    inhibitory interneuron;    synapse;    dendritic spine;   

DOI  :  10.3389/fnmol.2023.1292685

 received in 2023-09-11, accepted in 2023-10-11,  发布年份 2023

来源: Frontiers

【 摘 要 】

Motor learning is crucial for the survival of many animals. Acquiring a new motor skill involves complex alterations in both local neural circuits in many brain regions and long-range connections between them. Such changes can be observed anatomically and functionally. The primary motor cortex (M1) integrates information from diverse brain regions and plays a pivotal role in the acquisition and refinement of new motor skills. In this review, we discuss how motor learning affects the M1 at synaptic, cellular, and circuit levels. Wherever applicable, we attempt to relate and compare findings in humans, non-human primates, and rodents. Understanding the underlying principles shared by different species will deepen our understanding of the neurobiological and computational basis of motor learning.

【 授权许可】

Unknown   
Copyright © 2023 Kogan, Lu and Zuo.