Global metabolic profile and multiple phytometabolites in the different varieties of Gastrodia elata Blume

Frontiers in Plant Science

Plant Science

Shunxing Guo¹  Jiaxue Li¹  Tongyao Chen¹  Yuanyuan Li¹  Xu Zeng¹ 

[1] Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;

关键词: Gastrodia elata;    variety;    phytometabolite;    aromatic compounds;    HPLC fingerprints;   

DOI  :  10.3389/fpls.2023.1249456

 received in 2023-06-28, accepted in 2023-09-26,  发布年份 2023

来源: Frontiers

【 摘 要 】

Gastrodia elata Blume (Tianma in Chinese), a myco-heterotrophic orchid, is widely distributed in China. Tubers derived from this orchid are traditionally used as both medicinal and edible materials. At present, five primary varieties of G. elata are recorded in the “Flora of China.” Among them, the three main varieties currently in artificial cultivation are G. elata f. elata (GR, red stem), G. elata f. glauca (GB, black stem), and G. elata f. viridis (GG, green stem). In our study, the metabolic profiles and chemical composition of these three varieties were determined via UPLC-MS/MS and HPLC-UV. In total, 11,132 metabolites were detected, from which multiple phytometabolites were identified as aromatic compounds, heteroatomic compounds, furans, carbohydrates, organic acids, and their derivatives. A number of differentially expressed metabolites (DEMs) were annotated as bioactive ingredients. Overall, parishins, vanilloloside, and gastrodin A/B in the GB group were markedly higher, whereas gastrodin, gastrol, and syringic acid were more enriched in the GG or GR groups. Moreover, HPLC fingerprint analysis also found six metabolites used as markers for the identification of Gastrodiae Rhizoma in the Chinese Pharmacopoeia, which were also typical DEMs in metabolomics. Of these, gastrodin, 4-hydroxybenzyl alcohol, citric acid, and adenosine were quantitatively detected, showing a similar result with the metabolomic data. In summary, our findings provide novel insights into the phytochemical ingredients of different G. elata varieties, highlighting diverse biological activities and healthcare value.

【 授权许可】

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Copyright © 2023 Zeng, Li, Chen, Li and Guo