Preoperative hematocrit levels and postoperative mortality in patients undergoing craniotomy for brain tumors

Frontiers in Oncology

Oncology

Yu Zhang¹  Miao He²  Liyuan Peng³  Lvlin Chen³  Weelic Chong⁴  Yangchun Xiao⁵  Tiangui Li⁶  Pengfei Hao⁷  Lu Jia⁷  Jialing He⁸  Chao You⁸  Yixin Tian⁸  Fang Fang⁸  Xin Cheng⁸  Yang Hai⁹ 

[1] Center for Evidence Based Medical, Clinical Medical College and Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China;Department of Anesthesia, Clinical Medical College and Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China;Department of Critical Care Medicine, Clinical Medical College and Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China;Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, United States;Department of Neurosurgery, Clinical Medical College and Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China;Department of Neurosurgery, Longquan Hospital, Chengdu, Sichuan, China;Department of Neurosurgery, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi, China;Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China;Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States;

关键词: hematocrit;    anemia;    polycythemia;    mortality;    brain tumor;    craniotomy;   

DOI  :  10.3389/fonc.2023.1246220

 received in 2023-06-24, accepted in 2023-10-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundAbnormal hematocrit values, including anemia and polycythemia, are common in patients undergoing craniotomy, but the extent to which preoperative anemia or polycythemia independently increases the risk of mortality is unclear. This retrospective cohort study aimed to examine the association between preoperative anemia and polycythemia and postoperative mortality in patients who underwent craniotomy for brain tumor resection.MethodsWe retrospectively analyzed data from 12,170 patients diagnosed with a brain tumor who underwent cranial surgery at West China Hospital between January 2011 and March 2021. The preoperative hematocrit value was defined as the last hematocrit value within 7 days before the operation, and patients were grouped according to the severity of their anemia or polycythemia. We assessed the primary outcome of 30-day postoperative mortality using logistic regression analysis adjusted for potential confounding factors.ResultsMultivariable logistic regression analysis reported that the 30-day mortality risk was raised with increasing severity of both anemia and polycythemia. Odds ratios for mild, moderate, and severe anemia were 1.12 (95% CI: 0.79–1.60), 1.66 (95% CI: 1.06–2.58), and 2.24 (95% CI: 0.99–5.06), respectively. Odds ratios for mild, moderate, and severe polycythemia were 1.40 (95% CI: 0.95–2.07), 2.81 (95% CI: 1.32–5.99), and 14.32 (95% CI: 3.84–53.44), respectively.ConclusionsThis study demonstrated that moderate to severe anemia and polycythemia are independently associated with increased postoperative mortality in patients undergoing craniotomy for brain tumor resection. These findings underscore the importance of identifying and managing abnormal hematocrit values before craniotomy surgery.

【 授权许可】

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Copyright © 2023 Xiao, Cheng, Jia, Tian, He, He, Chen, Hao, Li, Chong, Hai, You, Peng, Fang and Zhang