Unraveling molecular networks in thymic epithelial tumors: deciphering the unique signatures

Frontiers in Immunology

Immunology

Zhijia Xia¹  Pengpeng Zhang²  Yanlong Feng³  Ansheng Cong⁴  Hao Chi⁵  Hailin Tang⁶  Xiao Zhang⁷ 

[1] Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians University Munich, Munich, Germany;Department of Lung Cancer Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China;Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China;Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Nephrology, Guangzhou, China;School of Clinical Medical Sciences, Southwest Medical University, Luzhou, China;State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China;State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China;Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China;

关键词: thymic epithelial tumors;    thymoma;    thymic carcinoma;    molecular;    genomic;    cellular signaling network;   

DOI  :  10.3389/fimmu.2023.1264325

 received in 2023-07-20, accepted in 2023-09-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

Thymic epithelial tumors (TETs) are a rare and diverse group of neoplasms characterized by distinct molecular signatures. This review delves into the complex molecular networks of TETs, highlighting key aspects such as chromosomal abnormalities, molecular subtypes, aberrant gene mutations and expressions, structural gene rearrangements, and epigenetic changes. Additionally, the influence of the dynamic tumor microenvironment on TET behavior and therapeutic responses is examined. A thorough understanding of these facets elucidates TET pathogenesis, offering avenues for enhancing diagnostic accuracy, refining prognostic assessments, and tailoring targeted therapeutic strategies. Our review underscores the importance of deciphering TETs’ unique molecular signatures to advance personalized treatment paradigms and improve patient outcomes. We also discuss future research directions and anticipated challenges in this intriguing field.

【 授权许可】

Unknown   
Copyright © 2023 Zhang, Zhang, Cong, Feng, Chi, Xia and Tang