Locomotor and respiratory muscle abnormalities in HFrEF and HFpEF

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Axel Linke¹  Ephraim B. Winzer¹  Norman Mangner¹  Volker Adams² 

[1] Department of Internal Medicine and Cardiology, Heart Center Dresden, Technische Universität Dresden, Dresden, Germany;Laboratory of Molecular and Experimental Cardiology, Heart Center Dresden, Technische Universität Dresden, Dresden, Germany;Dresden Cardiovascular Research Institute and Core Laboratories GmbH, Dresden, Germany;

关键词: HFrEF;    HFpEF;    skeletal muscle;    diaphragm;    sarcopenia;    cachexia;   

DOI  :  10.3389/fcvm.2023.1149065

 received in 2023-01-20, accepted in 2023-10-02,  发布年份 2023

来源: Frontiers

【 摘 要 】

Heart failure (HF) is a chronic and progressive syndrome affecting worldwide billions of patients. Exercise intolerance and early fatigue are hallmarks of HF patients either with a reduced (HFrEF) or a preserved (HFpEF) ejection fraction. Alterations of the skeletal muscle contribute to exercise intolerance in HF. This review will provide a contemporary summary of the clinical and molecular alterations currently known to occur in the skeletal muscles of both HFrEF and HFpEF, and thereby differentiate the effects on locomotor and respiratory muscles, in particular the diaphragm. Moreover, current and future therapeutic options to address skeletal muscle weakness will be discussed focusing mainly on the effects of exercise training.

【 授权许可】

Unknown   
© 2023 Mangner, Winzer, Linke and Adams.