Abdominal obesity in Chinese patients undergoing hemodialysis and its association with all-cause mortality

Frontiers in Endocrinology

Endocrinology

Pengpeng Ye¹  Zhihua Shi²  Yidan Guo²  Yang Luo² 

[1] Division of Injury Prevention and Mental Health, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China;Division of Nephrology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China;

关键词: abdominal obesity cohort study;    hemodialysis;    waist circumference;    body mass index;    all-cause mortality;   

DOI  :  10.3389/fendo.2023.1287834

 received in 2023-09-02, accepted in 2023-10-16,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionObesity in patients undergoing hemodialysis is common. However, there is limited information on the relationship between obesity types defined by the combined body mass index (BMI) and waist circumference (WC) classification criteria and all-cause mortality in Chinese hemodialysis patients. Our objective was to determine the association between obesity types and all-cause mortality in hemodialysis patients.MethodsWe conducted a prospective cohort study including patients from 11 hemodialysis centers in Beijing. According to the World Health Organization’s standards, patients were classified into 2 categories with WC and 4 categories with BMI and then followed up for 1 year. Kaplan–Meier survival analysis was used to compare the difference in the cumulative survival rate in different BMI and WC groups. A multivariate Cox regression analysis was used to determine the association between different types of obesity and all-cause mortality. ResultsA total of 613 patients were enrolled, the mean age was 63.8 ± 7.1 years old, and 42.1% were women. Based on the baseline BMI, there were 303 (49.4%) patients with normal weight, 227 (37.0%) with overweight, 37(6.0%) with obesity, and 46 (7.5%) with underweight. Based on the baseline WC, 346 (56.4%) patients had abdominal obesity. During a median follow-up of 52 weeks, 69 deaths occurred. Kaplan–Meier plots demonstrated a significant association of BMI categories (log-rank χ2 = 18.574, p<0.001) and WC categories (log-rank χ2 = 5.698, p=0.017) with all-cause death. With normal BMI and non-abdominal obesity as a reference, multivariate Cox regression analysis results showed that obesity (HR 5.36, 95% CI, 2.09-13.76, p<0.001), underweight (HR, 5.29, 95% CI, 2.32-12.07, p<0.001), normal weight combined with abdominal obesity (HR 2.61, 95% CI, 1.20-5.66, p=0.016), and overweight combined with abdominal obesity (HR 1.79, 95% CI, 1.03-3.73, p=0.031, respectively) were significantly associated with higher risks of all-cause mortality.ConclusionOur study indicated that abdominal obesity is common and associated with all-cause mortality among Chinese hemodialysis patients.

【 授权许可】

Unknown   
Copyright © 2023 Shi, Guo, Ye and Luo