Exploring the brain epitranscriptome: perspectives from the NSAS summit

Frontiers in Neuroscience

Neuroscience

Jean-Yves Roignant¹  André Fischer²  Kathy Liu³  Kate D. Meyer⁴  Bonsang Koo⁵  Ajeet Kumar⁵  Sung-Min Lee⁵  Ki-Jun Yoon⁵  Chuan He⁶  Yinsheng Wang⁷  Yanhong Shi⁸  Guo-li Ming⁹  Hongjun Song^1,10  Yi-Lan Weng^1,11  Shuying Sun^1,12  Junmin Peng^1,13  Erik Storkebaum^1,14  Davide De Pietri Tonelli^1,15  Luigi Pulvirenti^1,16  Clément Carré^1,17 

[1] Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland;Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg-University Mainz, Mainz, Staudingerweg, Germany;Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany;Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, United States;Department of Biochemistry, Duke University School of Medicine, Durham, NC, United States;Department of Neurobiology, Duke University School of Medicine, Durham, NC, United States;Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea;KAIST Stem Cell Center, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea;Department of Chemistry, Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, United States;Department of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, United States;Department of Chemistry, University of California, Riverside, CA, United States;Department of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, Duarte, CA, United States;Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States;Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, United States;Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States;Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States;Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States;Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, United States;Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States;The Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States;Department of Neurosurgery, Houston Methodist Neurological Institute, Houston, TX, United States;Department of Physiology and Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD, United States;Department of Structural Biology, St. Jude Children's Research Hospital, Danny Thomas Place, Memphis, TN, United States;Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Danny Thomas Place, Memphis, TN, United States;Donders Institute for Brain, Cognition and Behaviour and Faculty of Science, Radboud University, Nijmegen, Netherlands;Neurobiology of miRNA, Fondazione Istituto Italiano di Tecnologia (IIT), Genova, Italy;Neuroscience School of Advanced Studies, London, United Kingdom;Transgenerational Epigenetics & Small RNA Biology, Centre National de la Recherche Scientifique, Laboratoire de Biologie du Développement - Institut de Biologie Paris Seine, Sorbonne Université, Paris, France;

关键词: RNA modifications;    epitranscriptome;    neuroepitranscriptomics;    neurodevelopment;    neurogenesis;    glioblastoma;   

DOI  :  10.3389/fnins.2023.1291446

 received in 2023-09-09, accepted in 2023-10-10,  发布年份 2023

来源: Frontiers

【 摘 要 】

Increasing evidence reinforces the essential function of RNA modifications in development and diseases, especially in the nervous system. RNA modifications impact various processes in the brain, including neurodevelopment, neurogenesis, neuroplasticity, learning and memory, neural regeneration, neurodegeneration, and brain tumorigenesis, leading to the emergence of a new field termed neuroepitranscriptomics. Deficiency in machineries modulating RNA modifications has been implicated in a range of brain disorders from microcephaly, intellectual disability, seizures, and psychiatric disorders to brain cancers such as glioblastoma. The inaugural NSAS Challenge Workshop on Brain Epitranscriptomics hosted in Crans-Montana, Switzerland in 2023 assembled a group of experts from the field, to discuss the current state of the field and provide novel translational perspectives. A summary of the discussions at the workshop is presented here to simulate broader engagement from the general neuroscience field.

【 授权许可】

Unknown   
Copyright © 2023 Lee, Koo, Carré, Fischer, He, Kumar, Liu, Meyer, Ming, Peng, Roignant, Storkebaum, Sun, De Pietri Tonelli, Wang, Weng, Pulvirenti, Shi, Yoon and Song.