Quantification of global myocardial oxygenation in humans: initial experience

Journal of Cardiovascular Magnetic Resonance

Technical Notes

Matt Lyons¹  Kyle S McCommis¹  Jie Zheng¹  Pamela K Woodard¹  Robert O'Connor¹  Robert J Gropler¹  Donna Lesniak¹ 

[1] Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd, 63110, St. Louis, MO, USA;

关键词: Cardiovascular Magnetic Resonance;    Myocardial Blood Flow;    Coronary Sinus;    Mean Transit Time;    Rate Pressure Product;   

DOI  :  10.1186/1532-429X-12-34

 received in 2010-01-11, accepted in 2010-06-02,  发布年份 2010

来源: Springer

【 摘 要 】

PurposeTo assess the feasibility of our newly developed cardiovascular magnetic resonance (CMR) methods to quantify global and/or regional myocardial oxygen consumption rate (MVO2) at rest and during pharmacologically-induced vasodilation in normal volunteers.MethodsA breath-hold T2 quantification method is developed to calculate oxygen extraction fraction (OEF) and MVO2 rate at rest and/or during hyperemia, using a two-compartment model. A previously reported T2 quantification method using turbo-spin-echo sequence was also applied for comparison. CMR scans were performed in 6 normal volunteers. Each imaging session consisted of imaging at rest and during adenosine-induced vasodilation. The new T2 quantification method was applied to calculate T2 in the coronary sinus (CS), as well as in myocardial tissue. Resting CS OEF, representing resting global myocardial OEF, and myocardial OEF during adenosine vasodilation were then calculated by the model. Myocardial blood flow (MBF) was also obtained to calculate MVO2, by using a first-pass perfusion imaging approach.ResultsThe T2 quantification method yielded a hyperemic OEF of 0.37 ± 0.05 and a hyperemic MVO2 of 9.2 ± 2.4 μmol/g/min. The corresponding resting values were 0.73 ± 0.05 and 5.2 ± 1.7 μmol/g/min respectively, which agreed well with published literature values. The MVO2 rose proportionally with rate-pressure product from the rest condition. The T2 sensitivity is approximately 95% higher with the new T2 method than turbo-spin-echo method.ConclusionThe CMR oxygenation method demonstrates the potential for non-invasive estimation of myocardial oxygenation, and should be explored in patients with altered myocardial oxygenation.

【 授权许可】

Unknown   
© McCommis et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.