Epidemiology of CTX-M-type extended-spectrum beta-lactamase (ESBL)-producing nosocomial -Escherichia coli infection in China

Annals of Clinical Microbiology and Antimicrobials

Research

Xiaolan Yong¹  Qianyi Ou²  Fengjun Sun²  Wei Feng²  Jianhong Chen²  Peiyuan Xia²  Huiqing Shi³ 

[1] Department of Clinical Pharmacy, General Hospital of Chengdu Military Region, 610083, Chengdu, Sichuan Province, China;Department of Pharmacy, Southwest Hospital, Third Military Medical University, 400038, Chongqing, China;Department of Pharmacy, Southwest Hospital, Third Military Medical University, 400038, Chongqing, China;Department of Clinical Pharmacy, General Hospital of Chengdu Military Region, 610083, Chengdu, Sichuan Province, China;

关键词: Escherichia coli;    Epidemiology;    Extended-spectrum beta-lactamase;    Multilocus sequence typing;    Nosocomial infection;   

DOI  :  10.1186/s12941-015-0063-7

 received in 2014-10-08, accepted in 2015-01-08,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundEscherichia coli is one of the most common clinical pathogens causing nosocomial infection. The widespread cefotaxime-beta lactamases (CTX) has increased the multidrug resistance (MDR) of E. coli and has brought great trouble to the doctor treating the infection.MethodsESBL-positive E. coli isolates were collected from different hospitals in different areas and the minimal inhibitory concentration (MIC) was analyzed by the agar dilution method. The resistance gene types were detected using polymerase chain reaction (PCR) and the sequence types were determined by multilocus sequence typing (MLST).ResultsWe found that the blaCTX-M-1 group and the blaCTX-M-9 group were the main CTX-M gene types, with many kinds of MLST gene types. Except for TEM with high isolate, SHV, OXA and VEB were relatively rare, while no PER and GES was detected. Most strains may have other resistance mechanisms, and the ESBL positive strains have high resistance not only to cephalosporins but also to other kinds of antibiotics.ConclusionThe study provides wide epidemiological data and enables more effective infection control and treatment plans.

【 授权许可】

Unknown   
© Shi et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.