Supplement of levosimendan to epinephrine improves initial resuscitation outcomes from asphyxial cardiac arrest

BMC Anesthesiology

Research Article

Yong G. Peng¹  Nana Bao²  Bingjing Wu²  Linmin Pan²  Jiaojiao Dong²  Shishi Zhao²  Quanguang Wang³  Xuzhong Xu³ 

[1] Department of Anesthesiology, College of Medicine, University of Florida Shands Hospital, Gainesville, FL, USA;Department of Anesthesiology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou City, Zhejiang Province, China;Department of Anesthesiology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou City, Zhejiang Province, China;The First Affiliated Hospital, Wenzhou Medical University, South Baixiang Rd, 325000, Wenzhou City, Zhejiang Province, China;

关键词: Asphyxia;    Cardiac arrest;    Epinephrine;    Levosimendan;    CPR;   

DOI  :  10.1186/s12871-017-0309-3

 received in 2016-04-21, accepted in 2017-01-23,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundLevosimendan exerted favorable effects on the initial outcome in the treatment of ventricular fibrillation cardiac arrest. This study investigated the efficacy of levosimendan in the treatment of asphyxia-induced cardiac arrest in rats.MethodsAnimals underwent asphyxial cardiac arrest/cardiopulmonary resuscitation, randomized to three treatment groups: epinephrine (10 μg/kg) supplemented with levosimendan (bolus 12 μg/kg and infusion for 1 h, EL group); epinephrine only (10 μg/kg, E group), or levosimendan only (bolus 12 μg/kg and infusion for 1 h, L group). The resuscitation success rate, wet-to-dry ratio of lung, and rate of alveolar and blood gas analysis were recorded.Results10 rats in the EL group, 8 in the E group, and 2 in the L group showed an initial return of spontaneous circulation (P < 0.001); among them, 10, 4, and 2 rats survived at the end of a 60-min observation period from each group, respectively (P = 0.001). The coronary perfusion pressure in the EL group was higher than that of either the E or L group (P < 0.05). The lung wet-to-dry weight ratio and rate of damaged alveoli were lower in the EL group than the E group (P < 0.05).ConclusionsIn the early stage of resuscitation for asphyxia-induced cardiac arrest in rats, levosimendan supplemented with epinephrine can significantly increase coronary perfusion pressure, reduce lung injury, and ultimately enhance the survival rate.

【 授权许可】

CC BY   
© The Author(s). 2017