Analysis of the expression of Kv10.1 potassium channel in patients with brain metastases and glioblastoma multiforme: impact on survival

BMC Cancer

Research Article

Walter Stühmer¹  Sabine Martin¹  Luis Pardo²  Julian Schell³  Veit Rohde³  Andrea Reichmann³  Ramón Martínez³ 

[1] Department of Molecular Biology of Neuronal Signals, Max-Planck Institute for Experimental Medicine, Hermann-Rein-Str. 3, 37075, Goettingen, Germany;Department of Molecular Biology of Neuronal Signals, Max-Planck Institute for Experimental Medicine, Hermann-Rein-Str. 3, 37075, Goettingen, Germany;Department of Neurosurgery and Neurotraumatology, Bergmannsheil Hospital, University of Bochum, Bochum, Germany;Department of Neurosurgery, University of Goettingen, Robert-Koch-Str. 40, 37075, Goettingen, Germany;

关键词: Kv10.1;    Potassium channel;    Ion-channel;    Brain metastases;    Glioblastoma multiforme;    Protein expression;    Survival time;    Tricyclic antidepressants;    Tailored therapy;   

DOI  :  10.1186/s12885-015-1848-y

 received in 2015-04-23, accepted in 2015-10-26,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundKv10.1, a voltage-gated potassium channel only detected in the healthy brain, was found to be aberrantly expressed in extracerebral cancers. Investigations of Kv10.1 in brain metastasis and glioblastoma multiforme (GBM) are lacking.MethodsWe analyzed the expression of Kv10.1 by immunohistochemistry in these brain tumors (75 metastasis from different primary tumors, 71 GBM patients) and the influence of a therapy with tricyclic antidepressants (which are Kv10.1 blockers) on survival. We also investigated Kv10.1 expression in the corresponding primary carcinomas of metastases patients.ResultsWe observed positive Kv10.1 expression in 85.3 % of the brain metastases and in 77.5 % of GBMs. Patients with brain metastases, showing low Kv10.1 expression, had a significantly longer overall survival compared to those patients with high Kv10.1 expression. Metastases patients displaying low Kv10.1 expression and also receiving tricyclic antidepressants showed a significantly longer median overall survival as compared to untreated patients.ConclusionsOur data show that Kv10.1 is not only highly expressed in malignant tumors outside CNS, but also in the most frequent cerebral cancer entities, metastasis and GBM, which remain incurable in spite of aggressive multimodal therapies. Our results extend the correlation between dismal prognosis and Kv10.1 expression to patients with brain metastases or GBMs and, moreover, they strongly suggest a role of tricyclic antidepressants for personalized therapy of brain malignancies.

【 授权许可】

CC BY   
© Martínez et al. 2015