Neurodevelopmental outcomes among 2- to 3-year-old children in Bangladesh with elevated blood lead and exposure to arsenic and manganese in drinking water

Environmental Health

Research

David C. Christiani¹  Maitreyi Mazumdar²  David C. Bellinger²  Ema G. Rodrigues²  Robert O. Wright³  Linda Valeri⁴  Molly L. Kile⁵  Md Omar Sharif Ibne Hasan⁶  Mostofa Golam⁶  Quazi Quamruzzaman⁶ 

[1] Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA;Department of Neurology, Boston Children’s Hospital, Boston, MA, USA;Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA;Department of Neurology, Harvard Medical School, Boston, MA, USA;Department of Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA;Department of Psychiatry (Biostatistics), McLean Hospital, Belmont, MA, USA;Department of Psychiatry, Harvard Medical School, Boston, MA, USA;Department of Public Health, Oregon State University, Corvallis, OR, USA;Dhaka Community Hospital, Dhaka, Bangladesh;

关键词: Arsenic;    Manganese;    Lead;    Cognitive function;   

DOI  :  10.1186/s12940-016-0127-y

 received in 2015-11-17, accepted in 2016-03-07,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe people of Bangladesh are currently exposed to high concentrations of arsenic and manganese in drinking water, as well as elevated lead in many regions. The objective of this study was to investigate associations between environmental exposure to these contaminants and neurodevelopmental outcomes among Bangladeshi children.MethodsWe evaluated data from 524 children, members of an ongoing prospective birth cohort established to study the effects of prenatal and early childhood arsenic exposure in the Sirajdikhan and Pabna Districts of Bangladesh. Water was collected from the family’s primary drinking source during the first trimester of pregnancy and at ages 1, 12 and 20–40 months. At age 20–40 months, blood lead was measured and neurodevelopmental outcomes were assessed using a translated, culturally-adapted version of the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III).ResultsMedian blood lead concentrations were higher in Sirajdikhan than Pabna (7.6 vs.

【 授权许可】

CC BY   
© Rodrigues et al. 2016