Blood lead is significantly associated with metabolic syndrome in Korean adults: an analysis based on the Korea National Health and Nutrition Examination Survey (KNHANES), 2008

Cardiovascular Diabetology

Original Investigation

Sang Youl Rhee¹  Sang Ouk Chin¹  Young Seol Young Seol Kim¹  You-Cheol Hwang¹  Suk Chon¹  Jeong-taek Woo¹  Dong Hyun Sinn² 

[1] Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, 1 Hoegi-dong, 130-702, Dongdaemoon-gu, Seoul, South Korea;Department of Medicine, Inje University College of Medicine, Seoul, South Korea;

关键词: Metabolic syndrome X;    Lead;    Metals;    Heavy;    Insulin resistance;    Korea;   

DOI  :  10.1186/1475-2840-12-9

 received in 2012-10-27, accepted in 2012-12-05,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundAlthough an association between low-level environmental heavy metal exposure and the incidence of metabolic syndrome (MS) has been hypothesized, little research on this topic has been conducted on a population-wide level.MethodsWe analyzed MS status and whole blood lead, mercury, cadmium, manganese, and creatinine-adjusted urine arsenic concentrations in 1,405 subjects, ≥ 20 years of age, who were registered for the Korea National Health and Nutrition Examination Survey, 2008.ResultsVarious demographic and biochemical parameters were associated with MS and blood heavy metal status. After adjusting for these variables, lead was the only heavy metal that was significantly associated with MS. Lead concentrations in subjects with MS were significantly higher than those in subjects without MS (p = 0.015). The prevalence of MS and a moderate/high risk for cardiovascular disease, as determined by Framingham risk score, also increased significantly according to the logarithmic transformation of the lead quartile (p < 0.001). The odds ratios and 95% confidence intervals for MS were 1.56 (0.90–2.71), 1.63 (0.94–2.83), and 2.57 (1.46–4.51) for the second, third, and fourth quartiles of the log-transformed lead quartile, respectively, as compared with those of the lowest quartile after multiple adjustments for confounding factors. Serum triglyceride level was the only MS diagnostic component significantly associated with lead level in a multiple linear regression analysis (p = 0.006).ConclusionsThese findings suggest that a higher prevalence of MS is associated with higher blood lead levels in the Korean population.

【 授权许可】

Unknown   
© Rhee et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.