Metabolic syndrome: definitions and controversies

BMC Medicine

Review

Eva Kassi¹  Gregory Kaltsas²  George Chrousos³  Panagiota Pervanidou³ 

[1] Department of Biochemistry, National and Kapodistrian University of Athens, Athens, Greece;Department of Pathophysiology, National and Kapodistrian University of Athens, Athens, Greece;First Department of Paediatrics, National and Kapodistrian University of Athens, Athens, Greece;

关键词: Waist Circumference;    Impaired Fasting Glucose;    International Diabetes Federation;    Cholesterol Education Program Adult Treatment;    Education Program Adult Treatment Panel;   

DOI  :  10.1186/1741-7015-9-48

 received in 2011-01-06, accepted in 2011-05-05,  发布年份 2011

来源: Springer

【 摘 要 】

Metabolic syndrome (MetS) is a complex disorder defined by a cluster of interconnected factors that increase the risk of cardiovascular atherosclerotic diseases and diabetes mellitus type 2. Currently, several different definitions of MetS exist, causing substantial confusion as to whether they identify the same individuals or represent a surrogate of risk factors. Recently, a number of other factors besides those traditionally used to define MetS that are also linked to the syndrome have been identified. In this review, we critically consider existing definitions and evolving information, and conclude that there is still a need to develop uniform criteria to define MetS, so as to enable comparisons between different studies and to better identify patients at risk. As the application of the MetS model has not been fully validated in children and adolescents as yet, and because of its alarmingly increasing prevalence in this population, we suggest that diagnosis, prevention and treatment in this age group should better focus on established risk factors rather than the diagnosis of MetS.

【 授权许可】

Unknown   
© Kassi et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.