期刊论文详细信息
BMC Cancer
Negative lymph node count is an independent prognostic factor for patients with rectal cancer who received preoperative radiotherapy
Research Article
Hao Lu1  Zhiqian Hu1  Xinxing Li1  Kai Xu1  Haolu Wang2  Xiaowen Liang2 
[1] Department of General Surgery, Changzheng Hospital, The Second Military Medical University, 415 S. Fengyang Road, 200003, Shanghai, China;Therapeutics Research Centre, School of Medicine, The University of Queensland, Princess Alexandra Hospital, 4102, Woolloongabba, QLD, Australia;
关键词: Rectal cancer;    Preoperative radiotherapy;    Negative lymph node;    Survival;   
DOI  :  10.1186/s12885-017-3222-8
 received in 2017-01-18, accepted in 2017-03-22,  发布年份 2017
来源: Springer
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【 摘 要 】

BackgroundNegative lymph node (NLN) count has been reported to provide more accurate prognostic information than the N stage alone in patients with rectal cancer (RC). Since preoperative radiotherapy (Pre-RT) can significantly affect the LN status, it is unclear whether NLN count still has prognostic value count on survival of patients with RC who received Pre-RT.MethodsIn this study, clinicopathological characteristics, number of positive LNs and survival time were collected from Surveillance, Epidemiology, and End Results Program (SEER)-registered RC patients. Univariate and multivariate Cox proportional hazards models were used to assess the risk factors for survival.ResultsX-tile plots identified 9 (P < 0.001) as the optimal cutoff NLN value to divide the patients into high and low risk subsets in terms of cause specific survival (CSS). NLN count was validated as independently prognostic factor in univariate and multivariate analysis (P < 0.001). Subgroup analysis showed that NLN count was an independently prognostic factor for patients with stage ypII (P = 0.002) and ypIII (P < 0.001).ConclusionsOur results firmly demonstrated that NLN count provides accurate prognostic information for RC patients with Pre-RT.

【 授权许可】

CC BY   
© The Author(s). 2017

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