Comparison of intima-media thickness and ophthalmic artery resistance index for assessing subclinical atherosclerosis in HIV-1-infected patients

Cardiovascular Ultrasound

Research

Pierfrancesco Grima¹  Roberto Chiavaroli¹  Mariangela Tana¹  Marcello Guido²  Antonella De Donno²  Antonella Zizza³ 

[1]Division of Infectious Diseases, HIV Centre, S. Caterina Novella Hospital, via Roma, 73013, Galatina, Italy

[2]Laboratory of Hygiene, Department of Biological and Environmental Sciences and Technologies, Faculty of Sciences, University of Salento, Lecce, Italy

[3]National Research Council, Institute of Clinical Physiology, Lecce, Italy

关键词: HIV;    cardiovascular risk;    atherosclerosis;    intima-media thickness;    ophthalmic artery resistance index;   

DOI  :  10.1186/1476-7120-9-9

 received in 2011-01-21, accepted in 2011-04-01,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundHuman immunodeficiency virus (HIV) infection and antiretroviral treatment are associated with metabolic and cardiovascular complications that potentially increase the risk of atherosclerosis and cardiovascular disease in this population. Measurement of arterial wall thickness has been used as a surrogate of extent, severity and progression of atherosclerosis. A cross-sectional cohort study was performed to compare the validity of two non-invasive arterial measures: carotid intima-media thickness (IMT), a parameter of atherosclerosis, and ophthalmic artery resistance index (OARI), an index of occlusive carotid artery disease.MethodsA total of 95 patients receiving highly active antiretroviral therapy (HAART) for more than 12 months were consecutively enrolled. IMT and OARI were measured by 7.5 MHz linear probe.ResultsThere was a significant linear increase in IMT and OARI values as the grade of cardiovascular risk (0.70 and 0.69 for very low risk, 0.86 and 0.72 for low risk and 0.98 and 0.74 for medium/high risk, p < 0.001). A IMT > 0.83 and an OARI > 0.72 were the most discriminatory values for predicting a cardiovascular risk ≥ 10% (sensibility 89.6% and 75.8%; sensitivity 70.5% and 68.4%; p < 0.001).ConclusionsOur data indicate that OARI may have a potential as a new precocious marker of subclinical atherosclerosis in HIV-1-infected patients.

【 授权许可】

CC BY   
© Grima et al; licensee BioMed Central Ltd. 2011