Anti-Mullerian hormone levels decline under hormonal suppression: a prospective analysis in fertile women after delivery

Reproductive Biology and Endocrinology

Research

Christian Bieglmayer¹  Wolf Dietrich²  Andrea Weghofer³  Iris Ortner⁴  David Barad⁵  Norbert Gleicher⁶ 

[1] Department of Medical Laboratory Diagnostics, Medical University Vienna, Austria;Department of Obstetrics & Gynecology, Medical University Vienna, Austria;Department of Obstetrics & Gynecology, General Hospital Mistelbach, Austria;Department of Obstetrics & Gynecology, Medical University Vienna, Austria;The Center for Human Reproduction (CHR), New York and The Foundation for Reproductive Medicine, Chicago, Illinois, USA;General Hospital Moedling, Austria;The Center for Human Reproduction (CHR), New York and The Foundation for Reproductive Medicine, Chicago, Illinois, USA;Department of Epidemiology and Social Medicine and Department of Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, New York, USA;The Center for Human Reproduction (CHR), New York and The Foundation for Reproductive Medicine, Chicago, Illinois, USA;Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA;

关键词: Polycystic Ovary Syndrome;    Ovarian Reserve;    Antral Follicle;    Infertile Patient;    Antral Follicle Count;   

DOI  :  10.1186/1477-7827-9-98

 received in 2011-04-28, accepted in 2011-07-21,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundAMH's reported stability during periods of hormonal change makes it a practical tool in assessing ovarian reserve. However, AMH declines with age and age-specific cut-offs remain to be established in women with proven fertility. This study aims to determine age-specific ranges of AMH in women with proven fertility.MethodsTwo hundred-ten fertile women, aged 18-40 years, were prospectively recruited for AMH measurements within 14 days after delivery and age stratified into 3 groups (18-30, 31-36 and 37-40 years). Eligibility required spontaneous conception within a maximal period of six months. Autoimmune diseases, chemotherapy, radiation, ovarian surgery and polycystic ovary syndrome precluded inclusion.Results95% confidence intervals of AMH declined with advancing female age from 0.9-1.1 to 0.6-0.9 and 0.2-0.4 ng/mL (P < 0.001). AMH levels were not statistically associated with day of blood draw after delivery or pregnancy characteristics. Neither were they predictive of resumption of menses. They, however, at all ages were lower than reported in the literature for infertile patients.ConclusionsLike infertile populations, fertile women demonstrate declining AMH with advancing age. Uniformly lower levels than in infertile women suggest that AMH levels do not appear as stable under all hormonal influences as previously reported.

【 授权许可】

CC BY   
© Weghofer et al; licensee BioMed Central Ltd. 2011