HOXA7 plays a critical role in metastasis of liver cancer associated with activation of Snail

Molecular Cancer

Research

Xinjin Guo¹  Xiaoyu Sun²  Shengguang Yuan³  Xingsi Liang³  Zhenran Wang³  Biao Lei³  Bo Li³  Qi Huang³  Yangchao Wei³  Bo Tang³  Shuiping Yu³  Jie Liu³  Songqing He³  Run Zhai³  Guangying Qi⁴  Fang Tang⁴ 

[1] Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, 116011, Dalian, Liaoning, People’s Republic of China;Department of Gastroenterology, First Affiliated Hospital of Dalian Medical University, 116011, Dalian, Liaoning, People’s Republic of China;Department of Hepatobiliary Surgery, Guilin Medical University, Affiliated Hospital, 541001, Guilin, Guangxi, People’s Republic of China;Laboratory of Liver Injury and Repair Molecular Medicine, Guilin Medical University, 541001, Guilin, Guangxi, People’s Republic of China;Department of Pathology and Physiopathology, Guilin Medical University, 541004, Guilin, Guangxi, People’s Republic of China;

关键词: HOXA7;    Metastasis;    Liver cancer;    Snail;   

DOI  :  10.1186/s12943-016-0540-4

 received in 2016-03-21, accepted in 2016-08-18,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundLiver cancer is one of the main causes of cancer-related death in human. HOXA7 has been proved to be related with several cancers.MethodThe expression levels of HOXA7 were examined by Western blot, qRT-PCR or ICH. MTT was used to detect the proliferative rate of liver cancer cells. The invasive abilities were examined by matrigel and transwell assay. The metastatic abilities of liver cancer cells were revealed in BALB/c nude mice.ResultsIn this report, we revealed that HOXA7 promoted metastasis of HCC patients. First, increased levels of HOXA7 were examined in liver cancer especially in metastatic liver cancer. Moreover, higher expression level of HOXA7 was associated with poorer prognosis of liver cancer patients. Overexpression of HOXA7 significantly enhanced proliferation, migration, invasion in vitro and tumor growth and metastasis in vivo meanwhile silencing HOXA7 significantly inhibited the aboves abilities of liver cancer cells. In this research, we identified that HOXA7 performed its oncogenic characteristics through activating Snail.ConclusionCollectively, we identify the critical role and possible mechanism of HOXA7 in metastasis of liver cancer which suggest that HOXA7 may be a potential therapeutic target of liver cancer patients.

【 授权许可】

CC BY   
© The Author(s). 2016