Association of CETP Taq1B and -629C > A polymorphisms with coronary artery disease and lipid levels in the multi-ethnic Singaporean population

Lipids in Health and Disease

Research

Yongjian Lu¹  Hongyuan Yang²  Nilmani Saha³  Naeimeh Tayebi³  Chew-Kiat Heng³  Hongzhe Li³ 

[1] Department of Biochemistry, National University of Singapore, Singapore, Singapore;Department of Biochemistry, National University of Singapore, Singapore, Singapore;School of Biotechnology and Biomolecular Sciences, The University of New South Wales, 2052, Sydney, Australia;Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;

关键词: Cholesteryl ester transfer protein;    629C;    TaqB1;    HDL-cholesterol;    Coronary artery disease;   

DOI  :  10.1186/1476-511X-12-85

 received in 2012-12-13, accepted in 2013-05-24,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundHyperlipidaemia is a major risk factor for coronary artery disease (CAD) and cholesteryl ester transfer protein (CETP) gene polymorphisms are known to be associated with lipid profiles.MethodsIn this study, we investigated the association of two polymorphisms in the CETP, Taq1B (rs708272) and -629C > A (rs1800775), with CAD and lipid levels HDL-C in 662 CAD + cases and 927 controls from the Singapore population comprising Chinese, Malays and Indians.ResultsTaqB2 frequency was significantly lowest in the Malays (0.43) followed by Chinese (0.47) and highest in the Indians (0.56) in the controls. The B2 allele frequency was significantly lower in the Chinese CAD + cases compared to the controls (p = 0.002). The absence of the B2 allele was associated with CAD with an OR 2.0 (95% CI 1.2 to 3.4) after adjustment for the confounding effects of age, smoking, BMI, gender, hypertension, dyslipidemia and diabetes mellitus. The B2 allele was significantly associated with higher plasma HDL-C levels in the Chinese men after adjusting for confounders. Associations with plasma apoA1 levels were significant only in the Chinese men for Taq1B and -629C > A. In addition, the Taq1B polymorphism was only associated with plasma Apo B and Lp(a) in the Malay men. Significant associations were only found in non-smoking subjects with BMI <50th percentile. In this study, the LD coefficients between the Taq1B and -629C > A polymorphisms seemed to be weak.ConclusionThe absence the Taq1B2 allele was associated with CAD in the Chinese population only and the minor allele of the Taq1B polymorphism of the CETP gene was significantly associated with higher plasma HDL-C levels in Chinese men.

【 授权许可】

Unknown   
© Lu et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.