Protective effect of corn peptides against alcoholic liver injury in men with chronic alcohol consumption: a randomized double-blind placebo-controlled study

Lipids in Health and Disease

Research

Xingchang Pan¹  Muyi Cai¹  Fan Yang²  Wenxian Wang²  Yanrong Li²  Hongwei Guo²  Yuhong Wu³  Shixiu Zhang⁴ 

[1] China National Research Institute of Food and Fermentation Industries, 100027, Beijing, China;Department of Nutrition and Food Hygiene, School of Public Health, and Key Laboratory of Public Health Safety (Ministry of Education), Fudan University, 200032, Shanghai, China;Department of Nutrition and Food Hygiene, School of Public Health, and Key Laboratory of Public Health Safety (Ministry of Education), Fudan University, 200032, Shanghai, China;School of Medicine, Hangzhou Normal University, 310036, Hangzhou, Zhejiang, China;Institute of Nutrition and Food Hygiene, School of Public Health, Shandong University, 250012, Jinan, China;

关键词: Corn peptides;    Hepatoprotective;    Oxidative stress;    Lipid profile;    Alcoholic liver injury;    Human study;   

DOI  :  10.1186/1476-511X-13-192

 received in 2014-07-25, accepted in 2014-12-09,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundCorn peptides (CPs) are a novel food prepared from corn gluten meal, which is a main by-product of the corn starch industry. Recently, significant beneficial effects of CPs on early alcoholic liver injury in rats and on acute alcoholic injury in mice were observed. To our knowledge, the present study is the first report showing that CPs supplementation has beneficial effects on lipid profile, oxidative stress and alcoholic liver injury in men with chronic alcohol consumption.MethodsA 9-week, randomized, double-blind, placebo-controlled study was conducted between September 2011 and August 2012 to assess the hepatoprotective effect of CPs. A total of 161 men were randomized to receive CPs (n = 53), whey protein (n = 54), or corn starch placebo (n = 54) at the same dose of 2 g twice daily. 146 participants completed the study. Serum lipid profile, serum markers of liver injury, oxidative stress and inflammation, and fatty liver based on the results of abdominal ultrasonography were assessed at the beginning and end of the intervention.ResultsCPs supplementation (4 g/d) for 9 weeks significantly lowered serum levels or activities of total cholesterol, triglyceride, alanine aminotransferase, aspartate aminotransferase, malondialdehyde and tumor necrosis factor-α, and significantly increased serum activities of superoxide dismutase and glutathione peroxidase, but the same dose of whey protein and corn starch (placebo) did not demonstrate these effects.ConclusionsOur results indicate that CPs may have protective effects on alcohol-induced liver damage via modulation of lipid metabolism and oxidative stress. CPs may potentially be used as a functional food for the management of alcoholic liver disease in subjects with chronic alcohol consumption.

【 授权许可】

Unknown   
© Wu et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.